| Company Name: |
Merck KGaA |
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
|
| | 1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(N-BOC-PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Basic information |
| | 1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(N-BOC-PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: 1mg/mL | | form | lyophilized solid | | color | white |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | 1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(N-BOC-PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Usage And Synthesis |
| Uses | A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki = 6 nM). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM. Also shown to inhibit the activity of cathepsin B and papain at higher concentrations (Ki = 510 nM and 1.2 µM, respectively). Does not significantly inhibit cathepsin L. | | Biological Activity | Cell permeable: yes', 'Primary Target
cathepsin K', 'Product does not compete with ATP.', 'Reversible: yes', 'Target Ki: 6 nM against cathepsin; 510 nM, 1.2 μM, against cathepsin B and papain, respectively |
| | 1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(N-BOC-PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Preparation Products And Raw materials |
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