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| | HIV (GP120) fragment (318-327) Basic information |
| Product Name: | HIV (GP120) fragment (318-327) | | Synonyms: | ARG-GLY-PRO-GLY-ARG-ALA-PHE-VAL-THR-ILE;HIV (GP120) (318-327);H-ARG-GLY-PRO-GLY-ARG-ALA-PHE-VAL-THR-ILE-OH;LYS-ALA-ARG-VAL-NLE-PHE: NO2-GLU-ALA-NLE-NH2 [KARV-NLE-F: NO2-EA-NLE-NH2];I-10, P18IIIB I10;L-Isoleucine, L-arginylglycyl-L-prolylglycyl-L-arginyl-L-alanyl-L-phenylalanyl-L-valyl-L-threonyl-;HIV (GP120) fragment (318-327) | | CAS: | 147841-68-7 | | MF: | C48H80N16O12 | | MW: | 1073.25 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | HIV (GP120) fragment (318-327) Chemical Properties |
| density | 1.43±0.1 g/cm3(Predicted) | | storage temp. | -15°C | | pka | 3.36±0.10(Predicted) | | Sequence | Arg-Gly-Pro-Gly-Arg-Ala-Phe-Val-Thr-Ile | | InChIKey | OPTVPTKXPSEPBD-JLHVISHLSA-N |
| | HIV (GP120) fragment (318-327) Usage And Synthesis |
| Uses | HIV gp120 (318-327) is a short sequence of the HIV-1 strain IIIB envelope peptide (rgpgrafvti) that corresponds to the conserved C-terminal region of the glycoprotein. HIV gp120 (318-327) is part of the HIV vaccine V3 peptide epitope, also known as the I10 peptide. However, HIV gp120 (318-327) lacks the A2 anchor residues recognized by epitope-specific CTLs but has structural features that confer promiscuous A2 binding[1][2]. | | References | [1] Kmieciak D, et al. The effect of deletion of the V3 loop of gp120 on cytotoxic T cell responses and HIV gp120-mediated pathogenesis. J Immunol. 1998 Jun 1;160(11):5676-83. PMID:9605175
[2] Gu L, et al. A recombinant adenovirus-based vector elicits a specific humoral immune response against the V3 loop of HIV-1 gp120 in mice through the "Antigen Capsid-Incorporation" strategy. Virol J. 2014 Jun 16;11:112. DOI:10.1186/1743-422X-11-112 |
| | HIV (GP120) fragment (318-327) Preparation Products And Raw materials |
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