- 4-Hydroxyquinoline
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2026-08-07
- CAS:611-36-9
- Min. Order: 1kg
- Purity: 99%min
- Supply Ability: 100kgs
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| | 4-Quinolinol Basic information |
| | 4-Quinolinol Chemical Properties |
| Melting point | 200-202 °C(lit.) | | Boiling point | 264.27°C (rough estimate) | | density | 1.1555 (rough estimate) | | refractive index | 1.4500 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in methanol. | | form | Crystalline Powder or Needles | | pka | 2.23, 11.28(at 20℃) | | color | Light beige to yellow | | Water Solubility | 4.8g/L(15 ºC) | | BRN | 1524969 | | InChI | 1S/C9H7NO/c11-9-5-6-10-8-4-2-1-3-7(8)9/h1-6H,(H,10,11) | | InChIKey | PMZDQRJGMBOQBF-UHFFFAOYSA-N | | SMILES | Oc1ccnc2ccccc12 | | LogP | 2.450 (est) | | CAS DataBase Reference | 611-36-9(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Quinolinol(611-36-9) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | RTECS | VC4070000 | | HS Code | 29334900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 4-Quinolinol Usage And Synthesis |
| Description |
4-Hydroxyquinoline is a quinoline alkaloid that has been found in Z. lotus honeys. It is a core component of alkyl-4-hydroxyquinoline quorum sensing molecules such as 2-heptyl-3-hydroxy-4(1H)-quinolone and 2-nonyl-3-hydroxy-4-quinolone. 4-Hydroxyquinoline has been used as a precursor in the synthesis of compounds with antibacterial activity. It has also been used as a fluorescent detection reagent for iron(III) in bovine liver samples.
| | Chemical Properties | LIGHT BEIGE TO YELLOWISH CRYST. POWDER OR NEEDLES | | Uses | 4-Hydroxyquinolineis is a raw material in medical research, a hydroxylated quinoline derivative with antimicrobial activity. 4-Hydroxyquinoline showed growth-inhibitory effects against intestinal bacteria. 4-Hydroxyquinoline act as sacrifi
cial scavengers of the photogenerated oxygen species and has been shown to prevent the photodegradation of riboflavin. | | Definition | ChEBI: A monohydroxyquinoline carrying a hydroxy group at position 4. | | Synthesis Reference(s) | Journal of the American Chemical Society, 68, p. 1264, 1946 DOI: 10.1021/ja01211a038 | | General Description | 4-Quinolinol (4-quinolone) is a quinolone compound which forms the core moiety of antibacterials such as norfloxacin, nalidixic acid, ciprofloxacin and cinoxacin. | | Biological Activity | 4-hydroxyquinoline is a hydroxylated quinoline derivative with antimicrobial activity. it shows growth-inhibitory effects against intestinal bacteria. it also can be used as sacrificial scavengers of the photogenerated oxygen species. | | References | [1] F. KHALLOUKI. HPLC-ESI-MS and GC-EI-MS Identification and Quantitation of Polyphenolics and Alkaloids in Moroccan Jujube Honeys[J]. Journal of Apicultural Science, 2020, 64 1: 287-299. DOI: 10.2478/jas-2020-0029
[2] STEPHAN HEEB. Quinolones: from antibiotics to autoinducers[J]. FEMS microbiology reviews, 2011, 35 2: 247-274. DOI: 10.1111/j.1574-6976.2010.00247.x
[3] MARIE-GRATIA KAYIRERE . Synthesis and antibacterial activity of new 4-alkoxy, 4-aminoalkyl and 4-alkylthioquinoline derivatives[J]. European Journal of Medicinal Chemistry, 1998, 33 1: Pages 55-63. DOI: 10.1016/s0223-5234(99)80076-2
[4] GEORGE C. RAGOS Prodromos B I Mavroudis A Demertzis. A high-sensitive spectrofluorimetric method for the determination of micromolar concentrations of iron(III) in bovine liver with 4-hydroxyquinoline[J]. Farmaco (Societa chimica italiana: 1989), 1998, 53 8: Pages 611-616. DOI: 10.1016/s0014-827x(98)00070-6 |
| | 4-Quinolinol Preparation Products And Raw materials |
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