- 5-Bromo-2-methoxy-4-methylpyridine
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- $200.00 / 1KG
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2025-09-25
- CAS:164513-39-7
- Min. Order: 1KG
- Purity: 99%, 99.5% Sublimated
- Supply Ability: g-kg-tons, free sample is available
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| | 5-Bromo-2-methoxy-4-methylpyridine Basic information |
| | 5-Bromo-2-methoxy-4-methylpyridine Chemical Properties |
| Melting point | 33-37 °C(lit.) | | Boiling point | 229.6±35.0 °C(Predicted) | | density | 1.45g/ml | | Fp | 225 °F | | storage temp. | 0-10°C | | pka | 1.70±0.18(Predicted) | | form | powder to crystal | | color | White to Almost white | | InChI | 1S/C7H8BrNO/c1-5-3-7(10-2)9-4-6(5)8/h3-4H,1-2H3 | | InChIKey | HTBPXLJKMNBQMS-UHFFFAOYSA-N | | SMILES | COc1cc(C)c(Br)cn1 | | CAS DataBase Reference | 164513-39-7(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 5-Bromo-2-methoxy-4-methylpyridine Usage And Synthesis |
| Synthesis | Sodium acetate (3.54g. 43.23mmol) was added to a solution of 2-methoxy-4-methylpyridine (5.0g.3gmmol) in EtOAc (25mL). Br2 (1 .52mL, 58mmol) was added drop-wise to over 20 mm at 0°C. The RM was stirred at 50°C for 18 h. The total reaction mass was cooled, and after diluting it with water, the pH was adjusted to 8 with aq. NaOH. The organic layer was separated, and aq. Layer extracted with EtOAc (250mL x 3). The combined extract was washed with water (300 mL), brine (200 mL), dried (Na2SO4) and concentrated under reduced pressure to get a crude compound. The crude compound was purified by CC(silica gel 100-200mesh, 0-5 per cent EtOAc in PE) to obtain 5-bromo-2-methoxy-4-methylpyridine (2.82g. 40 per cent) as liquid.
| | References | [1] Patent: US2016/176882, 2016, A1. Location in patent: Paragraph 0355; 0356
[2] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00166 |
| | 5-Bromo-2-methoxy-4-methylpyridine Preparation Products And Raw materials |
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