|
|
| | 2-Amino-6-methyl-5-nitropyridine Basic information |
| | 2-Amino-6-methyl-5-nitropyridine Chemical Properties |
| Melting point | 185-189 °C | | Boiling point | 276.04°C (rough estimate) | | density | 1.3682 (rough estimate) | | refractive index | 1.6500 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 2.97±0.37(Predicted) | | form | Powder | | color | Yellow | | InChIKey | BGMZTBKXOFFTBJ-UHFFFAOYSA-N | | CAS DataBase Reference | 22280-62-2(CAS DataBase Reference) |
| Provider | Language |
|
ACROS
| English |
| | 2-Amino-6-methyl-5-nitropyridine Usage And Synthesis |
| Chemical Properties | Light yellow Cryst | | Synthesis | General procedure for the synthesis of 2-amino-5-nitro-6-methylpyridine from 2-amino-6-methylpyridine: 10 mL of concentrated sulfuric acid was cooled to 0-1 °C and 2-amino-6-methylpyridine (20 g) was slowly added, keeping the temperature at 0 °C. Subsequently, 110 mL of nitric acid in the ratio of 1:1 by volume was slowly added, stirred at -1 °C and continued stirring at room temperature for 30 min. The reaction mixture was warmed up to 50 °C for 11 hours. After completion of the reaction, the reaction solution was extracted with ethyl acetate (EA). The ethyl acetate layer was washed with ammonia and then the ammonia layer was concentrated. Eventually, the solid product 2-amino-5-nitro-6-methylpyridine (18 g) was precipitated in 75% yield. | | References | [1] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0019
[2] Patent: WO2005/42464, 2005, A1. Location in patent: Page/Page column 32-33
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 8, p. 1858 - 1868
[4] Patent: WO2009/30725, 2009, A2. Location in patent: Page/Page column 58
[5] Patent: EP1857444, 2007, A1. Location in patent: Page/Page column 20 |
| | 2-Amino-6-methyl-5-nitropyridine Preparation Products And Raw materials |
|