- C8-Ceramide
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- $68.00 / 2mg
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2026-01-05
- CAS:74713-59-0
- Min. Order:
- Purity:
- Supply Ability: 10g
- C8 CERAMIDE
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- $1.00 / 1KG
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2019-12-23
- CAS:74713-59-0
- Min. Order: 1KG
- Purity: 97%-99.9%
- Supply Ability: 100kg
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| | C8 CERAMIDE Basic information |
| | C8 CERAMIDE Chemical Properties |
| Melting point | 68-70°C | | Boiling point | 541.37°C (rough estimate) | | density | 0.9974 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | −20°C | | solubility | DMSO or ethanol: soluble | | form | waxy solid | | color | White | | Stability: | Temperature Sensitive | | InChIKey | APDLCSPGWPLYEQ-WRBRXSDHSA-N | | SMILES | C(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)(=O)CCCCCCC | | CAS DataBase Reference | 74713-59-0(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29225000 | | Storage Class | 11 - Combustible Solids |
| | C8 CERAMIDE Usage And Synthesis |
| Description | C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1Induces apoptosis.2Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver epithelial cells.3C8-ceramide induces the secretion of brain-derived neurotrophic factor (BDNF) from microgliain vitro.4 | | Chemical Properties | Off White Powder | | Uses | A biologically active, cell permeable, but nonphysiologic ceramide analog. It induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. It stimulates IL-2 secretion and induces apoptosis | | Uses | C-8 Ceramide is a ceramide analog. | | Definition | ChEBI: N-octanoylsphingosine is an N-acylsphingosine in which the ceramide N-acyl group is specified as octanoyl. It is functionally related to an octanoic acid. | | in vivo | C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8+ and CD4+ T cell responses to viral infections in virus infected mice[3].
| Animal Model: | C57BL/6 mice, with lymphocytic choriomeningitis virus infected[3] | | Dosage: | 0.1 mg/kg | | Administration: | Intranasal administration | | Result: | Increased the CD8+ T cell response to influenza in the lungs. |
| | IC 50 | PKC; apoptosis; autophagy | | References | [1] S MATHIAS R N K K A Dressler. Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1991, 88 22: 10009-10013. DOI:10.1073/pnas.88.22.10009
[2] W D JARVIS. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91 1: 73-77. DOI:10.1073/pnas.91.1.73
[3] BRAD L UPHAM . Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis[J]. Cancer letters, 2003, 191 1: Pages 27-34. DOI:10.1016/s0304-3835(02)00620-1
[4] KAZUYUKI NAKAJIMA. Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro[J]. Journal of Neurochemistry, 2002, 80 4: 697-705. DOI:10.1046/j.0022-3042.2001.00752.x |
| | C8 CERAMIDE Preparation Products And Raw materials |
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