4,4-DIMETHYL-2-OXAZOLIDINONE manufacturers
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| | 4,4-DIMETHYL-2-OXAZOLIDINONE Basic information |
| Product Name: | 4,4-DIMETHYL-2-OXAZOLIDINONE | | Synonyms: | 4,4-dimethyl-oxazolidin-2...;4,4-diMethyl-oxazolidin-2-one;ANTI-DMRTA1 (C-TERM) antibody produced in rabbit;DMRTA1;Doublesex- and mab-3-related transcription factor A1;DMO;4,4-DIMETHYL-2-OXAZOLIDINONE;4,4-Dimethyl-1,3-oxazolidin-2-one | | CAS: | 26654-39-7 | | MF: | C5H9NO2 | | MW: | 115.13 | | EINECS: | | | Product Categories: | | | Mol File: | 26654-39-7.mol |  |
| | 4,4-DIMETHYL-2-OXAZOLIDINONE Chemical Properties |
| Melting point | 55-56 °C(Solv: ethanol (64-17-5); ligroine (8032-32-4)) | | Boiling point | 152-154 °C(Press: 10 Torr) | | density | 1.039±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 12.91±0.40(Predicted) | | form | solid | | color | White to off-white | | InChI | 1S/C5H9NO2/c1-5(2)3-8-4(7)6-5/h3H2,1-2H3,(H,6,7) | | InChIKey | SYARCRAQWWGZKY-UHFFFAOYSA-N | | SMILES | CC1(C)COC(=O)N1 | | EPA Substance Registry System | 2-Oxazolidinone, 4,4-dimethyl- (26654-39-7) |
| WGK Germany | 3 | | TSCA | TSCA listed | | HS Code | 2934999090 | | Storage Class | 11 - Combustible Solids |
| | 4,4-DIMETHYL-2-OXAZOLIDINONE Usage And Synthesis |
| Synthesis | 4,4-Dimethyloxazolidin-2-one (DMO) was synthesized as follows: 2-amino-2-methyl-1-propanol (10.0 g, 112 mmol) was mixed with urea (13.5 g, 224 mmol), and the mixture was heated and reacted for 1 hour at 170-180 °C, followed by heating up to 210-220 °C and continued heating for 1 hour. After completion of the reaction, it was cooled to room temperature and the reaction mixture was dissolved in water (50 mL). Dichloromethane (DCM, 5 x 50 mL) extraction was performed with the aqueous solution. The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford 4,4-dimethyloxazolidin-2-one 10.3 g in 80% yield. The product was identified by 1H NMR (CDCl3): δ 6.13 (br s, 1H, NH), 4.07 (s, 2H, CH2), 1.32 (s, 6H, 2 CH3) ppm; 13C NMR (CDCl3) δ 159.4,77.1,55.4,27.7 ppm. | | References | [1] Asian Journal of Chemistry, 2011, vol. 23, # 2, p. 929 - 930
[2] Patent: WO2015/68159, 2015, A2. Location in patent: Paragraph 00121-00122 |
| | 4,4-DIMETHYL-2-OXAZOLIDINONE Preparation Products And Raw materials |
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