| Company Name: |
Cool Pharm, Ltd |
| Tel: |
021-60455363 18019463053 |
| Email: |
sales@coolpharm.com |
|
| | 5-(Chloromethyl)-8-quinolinol hydrochloride Basic information |
| Product Name: | 5-(Chloromethyl)-8-quinolinol hydrochloride | | Synonyms: | 5-(Chloromethyl)-8-hydroxyquinoline hydrochloride;8-quinolinol, 5-(chloromethyl)-;5-(Chloromethyl)-8-quinolinol;8-Quinolinol, 5-(chloromethyl)-, hydrochloride;Aids125750;Aids-125750;Nsc83066;5-(CHLOROMETHYL)QUINOLIN-8-OL HYDROCHLORIDE | | CAS: | 4053-45-6 | | MF: | C10H9Cl2NO | | MW: | 230.09 | | EINECS: | | | Product Categories: | | | Mol File: | 4053-45-6.mol |  |
| | 5-(Chloromethyl)-8-quinolinol hydrochloride Chemical Properties |
| Hazard Codes | Xi,Xn | | Risk Statements | 22 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 2933499090 |
| | 5-(Chloromethyl)-8-quinolinol hydrochloride Usage And Synthesis |
| Synthesis | 14.6 g (0.1 mol) of 8-hydroxyquinoline, 16 mL of 32% aqueous hydrochloric acid and 16 mL (0.1 mol) of 37% aqueous formaldehyde were mixed at 0°C and passed through hydrogen chloride gas to react for 6 hours. After completion of the reaction, the mixture was allowed to stand at room temperature for 2 hours without stirring. The yellow solid produced by the reaction was collected by filtration, washed with 90% ethanol and dried under vacuum to afford 5-(chloromethyl)-8-quinolinol hydrochloride (19.0 g, 98% yield). The structure of the product was confirmed by 1H NMR (250 MHz, CDCl3): δ 5.32 (s, 2H), 7.53 (m, 1H), 7.85 (m, 2H), 8.12 (m, 1H), 9.12 (m, 1H), 9.28 (m, 1H). | | References | [1] Journal of Medicinal Chemistry, 2014, vol. 57, # 24, p. 10455 - 10463
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 3, p. 773 - 783
[3] Patent: WO2012/20389, 2012, A1. Location in patent: Page/Page column 22
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 21, p. 8616 - 8637
[5] Journal of Molecular Liquids, 2016, vol. 219, p. 396 - 404 |
| | 5-(Chloromethyl)-8-quinolinol hydrochloride Preparation Products And Raw materials |
|