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| | 2-(Trifluoromethyl)benzyl alcohol Basic information |
| | 2-(Trifluoromethyl)benzyl alcohol Chemical Properties |
| Melting point | 4°C | | Boiling point | 90 °C20 mm Hg(lit.) | | density | 1.326 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.468(lit.) | | Fp | 198 °F | | storage temp. | Sealed in dry,Room Temperature | | form | clear liquid | | pka | 14.01±0.10(Predicted) | | color | Colorless to Almost colorless | | BRN | 2093714 | | CAS DataBase Reference | 346-06-5(CAS DataBase Reference) | | NIST Chemistry Reference | 2-(Trifluoromethyl)benzyl alcohol(346-06-5) |
| | 2-(Trifluoromethyl)benzyl alcohol Usage And Synthesis |
| Chemical Properties | Colorless to light yellow liqui | | Uses | 2-(Trifluoromethyl)benzyl alcohol has been used to investigate the aromatic aldehydes as substrate for yeast alcohol dehydrogenase. | | Definition | ChEBI: [2-(Trifluoromethyl)phenyl]methanol is a member of (trifluoromethyl)benzenes. | | Synthesis | (1) Water (348.0 g) was added to a 1000 mL three-necked round-bottomed flask equipped with a mechanical stirrer and a thermometer and cooled to 0°C. Subsequently, sodium borohydride (9.5 g, 0.25 mol) was added and stirred for 20 min. Maintaining the temperature at 5 °C, o-trifluoromethylbenzaldehyde (87.1 g, 0.5 mol) was slowly added dropwise. After the dropwise addition, the reaction temperature was maintained at 10 °C for 1 hour. After completion of the reaction, extraction was carried out by adding methyl tert-butyl ether. The organic phases were combined, washed with saturated brine and concentrated under reduced pressure to no fraction to obtain 2-trifluoromethylbenzenemethanol as a colorless transparent liquid with a purity of >99% and a yield of 90%. | | References | [1] Patent: CN106588673, 2017, A. Location in patent: Paragraph 0047; 0048
[2] Patent: CN106699729, 2017, A. Location in patent: Paragraph 0066; 0067
[3] Green Chemistry, 2015, vol. 17, # 9, p. 4537 - 4540
[4] Journal of Organic Chemistry, 2017, vol. 82, # 13, p. 6972 - 6977 |
| | 2-(Trifluoromethyl)benzyl alcohol Preparation Products And Raw materials |
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