1H-INDAZOL-4-AMINE

2942-40-7

41748-71-4

The general procedure for the synthesis of 4-aminoindazole from 4-nitroindazole is as follows: 1. 2-Methyl-3-nitroaniline (2.27 g, 14.91 mmol) was dissolved in acetic acid (60 mL) and an aqueous solution of sodium nitrite (1.13 g, 1.1 eq.) was added (5 mL). After 2 hours of reaction, the dark red solution was poured into ice/water and the precipitate was collected by filtration to give 4-nitro-1H-indazole (1.98 g, 81% yield). 2. 4-Nitro-1H-indazole (760 mg, 4.68 mmol), charcoal-loaded palladium (10%, catalyst), and ethanol (30 mL) were stirred under a hydrogen balloon for 4 hours. Upon completion of the reaction, the solvent was removed in vacuum by filtration through diatomaceous earth to afford 1H-indazol-4-ylamine (631 mg, 100% yield). 3. A suspension of 1H-indazol-4-ylamine (63 mg, 4.74 mmol) in 6 M hydrochloric acid (7.2 mL) was added dropwise to an aqueous solution (2 mL) of sodium nitrite (337 mg, 4.89 mmol) at below 0 °C. After stirring for 30 min, sodium tetrafluoroborate (724 mg) was added. The reaction mixture formed a viscous solution, which was filtered and washed briefly with water to give 1H-indazole-4-diazotetrafluoroborate (218 mg, 20% yield) as a dark red solid. 4. Dry methanol (4 mL) was purged with argon for 5 min and 1H-indazole-4-diazotetrafluoroborate (218 mg, 0.94 mmol), bis(pinacolato)diboron (239 mg, 1.0 eq.), and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) chloride (20 mg) were added. The reaction mixture was stirred for 5 hours and then filtered through diatomaceous earth. The residue was purified by fast chromatography to afford the target product 4-aminoindazole (117 mg).