| Company Name: |
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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| Tel: |
400-6206333 13167063860 |
| Email: |
anhua.mao@aladdin-e.com |
| Products Intro: |
Product Name:HC Toxin
CAS:83209-65-8
Purity:>=98% Package:1mg/RMB 2086.90;5mg/RMB 9234.90
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HC TOXIN manufacturers
- HC Toxin
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- $598.00 / 1mg
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2026-01-05
- CAS:83209-65-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | HC TOXIN Basic information |
| Product Name: | HC TOXIN | | Synonyms: | HC TOXIN FROM HELMINTHOSPORIUM CARBONUM;Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-];Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-];HC toxin I;Toxin I;Cyclic(L-alanyl-D-alanyl-eta-oxo-L-alpha-aminooxiraneoctanoyl-D-prolyl);Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine);Cyclo(aoe-Pro-Ala-ala) | | CAS: | 83209-65-8 | | MF: | C21H32N4O6 | | MW: | 436.51 | | EINECS: | | | Product Categories: | Cell Signaling and Neuroscience;Mold;Toxins and Venoms | | Mol File: | 83209-65-8.mol |  |
| | HC TOXIN Chemical Properties |
| Boiling point | 819.2±65.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 10 mg/ml; Methanol: 10 mg/ml | | form | lyophilized powder | | pka | 13.33±0.70(Predicted) | | color | Off-white to light yellow | | InChI | 1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28) | | InChIKey | GNYCTMYOHGBSBI-UHFFFAOYSA-N | | SMILES | CC1NC(=O)C(C)NC(=O)C2CCCN2C(=O)C(CCCCCC(=O)C3CO3)NC1=O |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | Storage Class | 6.1B - Non-combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Oral |
| | HC TOXIN Usage And Synthesis |
| Description | HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. | | Uses | HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2) | | Definition | ChEBI: A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues. | | Biochem/physiol Actions | Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype. | | References | [1] G BROSCH. Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum.[J]. Plant Cell, 1995, 7 11: 1941-1950. DOI: 10.1105/tpc.7.11.1941
[2] S J DARKIN-RATTRAY. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1996, 93 23: 13143-13147. DOI: 10.1073/pnas.93.23.13143
[3] H. KAMITANI. Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma.[J]. Carcinogenesis, 2001, 22 1 1: 187-191. DOI: 10.1093/carcin/22.1.187
[4] HUA CAO George S. Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin[J]. American Journal of Hematology, 2006, 81 12: 981-983. DOI: 10.1002/ajh.20676
[5] WALTON J. HC-toxin.[J]. Phytochemistry, 2020, 67 14 1: 1406-1413. DOI: 10.32388/5s7act |
| | HC TOXIN Preparation Products And Raw materials |
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