牛磺-Α-鼠胆酸
| 中文名称 | 牛磺-Α-鼠胆酸 |
|---|---|
| 中文同义词 | 牛磺-Α-鼠胆酸;牛磺-贝塔-鼠胆酸钠盐;化合物 TAURO-Ω-MURICHOLIC ACID SODIUM;牛磺-Β-鼠胆酸钠盐;牛磺酸Β-鼠胆酸钠盐;牛磺-B鼠胆酸钠盐;化合物 TAURO-Β-MURICHOLIC ACID SODIUM;牛磺-Β-鼠胆酸钠-[D5] |
| 英文名称 | Tauro--muricholic Acid (sodium salt) |
| 英文同义词 | Tauro-β-muricholic acid sodium;T-βMCA sodium;Tauro-β-muricholic Acid sodium salt;2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonicacid,monosodiumsalt;Tauro-β-Muricholic Acid-[d5] Sodium Salt;D4-Tauro-β-muricholic Acid Sodium Salt;Tauro-muricholic Acid (sodium salt);Tauro-β-muricholic acid sodium (Standard) |
| CAS号 | 145022-92-0 |
| 分子式 | C26H46NNaO7S |
| 分子量 | 539.7 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 145022-92-0.mol |
| 结构式 |  |
牛磺-Α-鼠胆酸 性质
| 熔点 | 120-125oC |
|---|---|
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | DMSO（少许）、甲醇（少许）、水（少许） |
| 形态 | 固体 |
| 颜色 | 白色至浅棕色 |
| 稳定性 | 吸湿性 |
Tauro-β-muricholic Acid sodium (T-βMCA sodium) 是一种内源性代谢物，是一种竞争性、可逆的 FXR 拮抗剂，其 IC50 值为 40 μM。
IC50: 40 μM (FXR)
T-βMCA sodium inhibits FXR reporter activity in the CRC cell line HT29 (EC
50
~10 μM).
T-βMCA sodium dose-dependently increases WNT signaling in HT29 and HCT116 cells.
T-βMCA sodium induces proliferation and DNA damage in Lgr5
+
cells.
T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression.
T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17.
| Animal Model: | APCmin/+ mice |
| Dosage: | 400 mg/kg |
| Administration: | Oral gavage; twice a week; for 6 weeks |
| Result: | Markedly decreased intestinal integrity and accelerated tumor growth in the intestine and colon. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-135103 | 牛磺-Α-鼠胆酸 Tauro-β-muricholic acid sodium | 145022-92-0 | 1mg | 1800元 |
| 2025/12/22 | HY-135103 | 牛磺-Α-鼠胆酸 Tauro-β-muricholic acid sodium | 145022-92-0 | 5 mg | 5000元 |