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| | 3-Bromophenylhydrazine hydrochloride Basic information |
| | 3-Bromophenylhydrazine hydrochloride Chemical Properties |
| Melting point | 227-231 °C (dec.)(lit.) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Powder | | color | Off-white to light brown | | Sensitive | Hygroscopic | | BRN | 3565829 | | InChI | 1S/C6H7BrN2.ClH/c7-5-2-1-3-6(4-5)9-8;/h1-4,9H,8H2;1H | | InChIKey | RPYIPFXHIKXRKS-UHFFFAOYSA-N | | SMILES | Cl.NNc1cccc(Br)c1 | | CAS DataBase Reference | 27246-81-7(CAS DataBase Reference) |
| Hazard Codes | C,Xi | | Risk Statements | 34-36/37/38 | | Safety Statements | 26-36/37/39-45-37/39 | | RIDADR | UN 1759 8/PG 2 | | WGK Germany | 2 | | RTECS | MV0815000 | | Hazard Note | Harmful | | HazardClass | IRRITANT, HYGROSCOPIC, TOXIC | | PackingGroup | Ⅱ | | HS Code | 29280000 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Eye Dam. 1
Skin Corr. 1B | | Toxicity | mouse,LD50,intravenous,200mg/kg (200mg/kg),Quarterly Journal of Crude Drug Research. Vol. 9, Pg. 1455, 1969. |
| | 3-Bromophenylhydrazine hydrochloride Usage And Synthesis |
| Chemical Properties | off-white to light brown powder | | Uses | A phenylhydrazone derivative with fungicidal activity. | | Uses | 3-Bromophenylhydrazine hydrochloride was used to prepare 6-(3-Bromophenylhydrazono)-7,8,9,11-tetrahydropyrido [2,1- b]quinazoline-11-one. | | Synthesis | (1) Diazotization: 3-bromoaniline and 37% concentrated hydrochloric acid were mixed and cooled to 0-5, 35% aqueous sodium nitrite was added while stirring, and the temperature was maintained at 0-5 for 1-1.5 hours. (2) reduction: add 37% concentrated hydrochloric acid, water and zinc powder in the reaction solution, keep the temperature between 15-20 reaction until the reaction is complete, the reaction solution becomes grayish-white, and then add 20-30% sodium hydroxide solution to the reaction solution PH 10, 5 holding time of 1-2 hours, precipitate crystals, filtered to get the crude 3-bromophenylhydrazine. (3) purification: 3-bromophenylhydrazine crude dissolved in water, heated to 60 C to make it completely dissolved, and then add an appropriate amount of activated carbon decolorization for 20 minutes, hot filtration of colorless filtrate, 5 C holding time of 1 ~ 2 hours, precipitation of crystals, filtration of 3-bromophenylhydrazine pure product. (4) Salt formation: 3-bromophenylhydrazine pure product dissolved in 37% hydrochloric acid, stirring at 60 ~ 70 until the reaction solution precipitated crystals, cooled to 20 , filtration, acetone drenching the filter cake, drying that is, 3-bromophenylhydrazine hydrochloride finished product. |
| | 3-Bromophenylhydrazine hydrochloride Preparation Products And Raw materials |
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