TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS
| 中文名称 | TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS |
|---|---|
| 中文同义词 | 2-甲基柠檬酸三钠 非对映异构体的混合物 (甲基-D3, 98%) 90%+ CP;2-甲基柠檬酸三钠 非标记非对映异构体的混合物 90%+ CP;2-甲基柠檬酸-D3三钠盐;2-Methylcitric acid trisodium #天然产物 HY-113371A;2-Methylcitric acid trisodium #天然产物 HY-113371A |
| 英文名称 | Trisodium (2RS,3RS)-2-methylcitrate |
| 英文同义词 | TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS;2-hydroxy-butane-1,2,3-tricarbonoic acid;2-Methylcitric acid trisodium;Methylcitric acid trisodium;Trisodium 2-methylcitrate, racemic mixture of diastereomers >=85% (mixture of diastereomers, NMR);Trisodium 2-methylcitrate;2-Methylcitrate-d3 Trisodium Salt;Trisodium (2RS,3RS)-2-methylcitrate |
| CAS号 | 117041-96-0 |
| 分子式 | C7H7O7*3Na |
| 分子量 | 230.15 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 117041-96-0.mol |
| 结构式 |  |
TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS 性质
| 储存条件 | Store at -20°C |
|---|---|
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| InChI | 1S/C7H10O7.3Na/c1-3(5(10)11)7(14,6(12)13)2-4(8)9;;;/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13);;;/q;3*+1/p-3 |
| InChIKey | HPLKAWNRQOHUKD-UHFFFAOYSA-K |
| SMILES | [Na+].[Na+].[Na+].CC(C([O-])=O)C(O)(CC([O-])=O)C([O-])=O |
|
Human Endogenous Metabolite
|
2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria.
2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca
2+
-loaded mitochondria supported by different substrates.
2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis.
2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport.
2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria.
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-113371A | 2-Methylcitric acid trisodium | 117041-96-0 | 1 mg | 1250元 |
| 2026/06/05 | HY-113371A | TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS 2-Methylcitric acid trisodium | 117041-96-0 | 5mg | 3500元 |