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| | 5-BROMOPYRIDINE-2-CARBONYL CHLORIDE Basic information |
| Product Name: | 5-BROMOPYRIDINE-2-CARBONYL CHLORIDE | | Synonyms: | 5-BROMOPYRIDINE-2-CARBONYL CHLORIDE;5-Bromopyridine-2-carbonyl chloride ,97%;5-Bromopyridine-2-carbonyl chloride, tech;5-BroMo-pyriMidine-2-carbonyl chloride;5-Bromo-2-(chlorocarbonyl)pyridine;5-BroMopyridine-2-carbonyl chloride, tech grade;5-Bromo-2-(chlorocarbonyl)pyridine, 5-Bromopicolinoyl chloride;2-Pyridinecarbonyl chloride, 5-bromo- | | CAS: | 137178-88-2 | | MF: | C6H3BrClNO | | MW: | 220.45 | | EINECS: | | | Product Categories: | | | Mol File: | 137178-88-2.mol |  |
| | 5-BROMOPYRIDINE-2-CARBONYL CHLORIDE Chemical Properties |
| Boiling point | 250 ºC | | density | 1.760 | | Fp | 105 ºC | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | Solid | | pka | -1.86±0.10(Predicted) | | Sensitive | Moisture Sensitive |
| HazardClass | IRRITANT | | HazardClass | 8 | | HS Code | 29333990 |
| | 5-BROMOPYRIDINE-2-CARBONYL CHLORIDE Usage And Synthesis |
| Chemical Properties | Brown solid | | Synthesis | General procedure for the synthesis of 5-bromo-pyridine-2-carbonyl chloride from 2-carboxylic acid-5-bromopyridine: To a solution of dichloromethane (80 mL) containing 5-bromo-pyridine-2-carboxylic acid (0.05 mmol), oxalyl chloride (0.24 mmol) and N,N-dimethylformamide (5 drops) were slowly added dropwise at room temperature. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give 5.4 g (100% yield) of 5-bromo-pyridine-2-carbonyl chloride. | | References | [1] Patent: CN103130792, 2016, B. Location in patent: Paragraph 0533
[2] Patent: WO2014/164749, 2014, A1. Location in patent: Page/Page column 312
[3] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00262
[4] Tetrahedron, 2005, vol. 61, # 45, p. 10748 - 10756
[5] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 7, p. 2074 - 2079 |
| | 5-BROMOPYRIDINE-2-CARBONYL CHLORIDE Preparation Products And Raw materials |
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