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| | 17-phenyl trinor Prostaglandin F2α 1,15-lactone Basic information |
| | 17-phenyl trinor Prostaglandin F2α 1,15-lactone Chemical Properties |
| solubility | DMF: 14 mg/ml
DMSO: 12.5 mg/ml
Ethanol: 16 mg/ml
Ethanol: PBS (pH 7.2) (1:1): 0.5 mg/ml |
| | 17-phenyl trinor Prostaglandin F2α 1,15-lactone Usage And Synthesis |
| Description | 17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) (Item No. 16810) is a metabolically stable analog of PGF2α (Item No. 16010) with potent FP receptor agonist activity and well known intraocular pressure-reducing effects.1,2,3 17-phenyl trinor PF2α 1,15-lactone is the 1,15 lactone of 17-phenyl-trinor PGF2α. Selective F-series PG derivatives such as this compound have been developed for suitable pharmacologic activity and an improved side-effect profile over current glaucoma therapeutics.4,5WARNING This product is not for human or veterinary use. | | References | [1] ANIL K. BALAPURE . Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor[J]. Biochemical pharmacology, 1989, 38 14: Pages 2375-2381. DOI: 10.1016/0006-2952(89)90478-4
[2] S. LAKE . Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor[J]. FEBS Letters, 1994, 355 3: Pages 317-325. DOI: 10.1016/0014-5793(94)01198-2
[3] D.F WOODWARD PHD. The Pharmacology of Bimatoprost (Lumigan™)[J]. Survey of ophthalmology, 2001, 45: Pages S337-S345. DOI: 10.1016/s0039-6257(01)00224-7
[4] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[5] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras. |
| | 17-phenyl trinor Prostaglandin F2α 1,15-lactone Preparation Products And Raw materials |
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