| Company Name: |
Shanghai Merlot Chemical Co., LTD
|
| Tel: |
15821661757 |
| Email: |
226174156@qq.com |
| Products Intro: |
Product Name:GSK2332255B
CAS:1366233-41-1
Purity:95% Package:1g；5g
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:GSK2332255B
CAS:1366233-41-1
Package:25mg/RMB 10600
|
|
| | GSK255B) Basic information |
| Product Name: | GSK255B) | | Synonyms: | GSK 2332255B
(GSK2332255B;GSK255B);Methanone, [5-chloro-2-[(6-fluoro-1,3-benzodioxol-5-yl)amino]-4-thiazolyl](2,3-dimethyl-1-piperidinyl)- | | CAS: | 1366233-41-1 | | MF: | C18H19ClFN3O3S | | MW: | 411.88 | | EINECS: | | | Product Categories: | | | Mol File: | 1366233-41-1.mol |  |
| | GSK255B) Chemical Properties |
| Boiling point | 542.7±60.0 °C(Predicted) | | density | 1.417±0.06 g/cm3(Predicted) | | pka | 0.46±0.10(Predicted) |
| | GSK255B) Usage And Synthesis |
| Description | GSK 2332255B is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 3 nM/21 nM, respectively. It dispalys >100-fold selectivity over other calcium-permeable channels. It has 100-fold greater potency for TRPC3 compared with Pyr3. GSK 2332255B (dose-dependent) blocks cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes. | | Uses | GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels[1]. | | IC 50 | rTRPC3: 5 nM (IC50); rTRPC6: 4 nM (IC50) | | References | [1] Kinya Seo, et al. Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1551-6. DOI:10.1073/pnas.1308963111 |
| | GSK255B) Preparation Products And Raw materials |
|