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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Product Name:PROTAC BRD9 Degrader-1
CAS:2097971-01-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | PROTAC BRD9 Degrader-1 Basic information |
| Product Name: | PROTAC BRD9 Degrader-1 | | Synonyms: | PROTAC BRD9 Degrader-1;Acetamide, N-[4-[[2-[4-[4,5-dihydro-2-[imino[(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)amino]methyl]-5-methyl-4-oxothieno[3,2-c]pyridin-7-yl]-2-methoxyphenoxy]acetyl]amino]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-;2-(4-{2-[N-(1,1-dioxo-1λ?-thian-4-yl)carbamimidoyl]-5-methyl-4-oxo-4H,5H-thieno[3,2-c]pyridin-7-yl}-2-methoxyphenoxy)-N-[4-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamido)butyl]acetamide;N-[4-[[2-[4-[4,5-Dihydro-2-[imino[(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)amino]methyl]-5-methyl-4-oxothieno[3,2-c]pyridin-7-yl]-2-methoxyphenoxy]acetyl]amino]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide | | CAS: | 2097971-01-0 | | MF: | C42H45N7O12S2 | | MW: | 903.98 | | EINECS: | | | Product Categories: | | | Mol File: | 2097971-01-0.mol |  |
| | PROTAC BRD9 Degrader-1 Chemical Properties |
| density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 150 mg/mL (165.93 mM) | | form | Solid | | pka | 10.68±0.40(Predicted) | | color | Light yellow to yellow |
| | PROTAC BRD9 Degrader-1 Usage And Synthesis |
| Uses | PROTAC BRD9 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD9 (IC50=13.5 nM), which can be used as a selective probe useful for the study of BAF complex biology[1]. | | IC 50 | BRD9: 13.5 nM (IC50); BRD4: 3.78 μM (IC50); CRBN-DDB1: 48.9 nM (IC50) | | References | [1] Remillard D, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743. DOI:10.1002/anie.201611281 |
| | PROTAC BRD9 Degrader-1 Preparation Products And Raw materials |
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