AMG 510 manufacturers
- AMG 510 USP/EP/BP
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- $1.10
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2026-08-20
- CAS:2252403-56-6
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons min
- (S)-AMG-510
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- $31.00
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2026-07-27
- CAS:2252403-56-6
- Purity: 99.05%
- Supply Ability: 10g
- AMG 510
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2026-07-01
- CAS:2252403-56-6
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kgs
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| Product Name: | AMG 510 | | Synonyms: | 6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-1-[4-METHYL-2-(PROPAN-2-YL)PYRIDIN-3-YL]-4-[(2S)-2-METHYL-4-(P;6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]-1H,2H-pyrido[2,3-d]pyrimidin-2-one;AMG-510;AMG 510;AMG510;AMG 510;4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one;chiral AMG 510, single isomer;CPD2809;AMG-510，AMG510 | | CAS: | 2252403-56-6 | | MF: | C30H30F2N6O3 | | MW: | 560.59 | | EINECS: | | | Product Categories: | GS | | Mol File: | 2252403-56-6.mol |  |
| | AMG 510 Chemical Properties |
| Boiling point | 730.5±70.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C, stored under nitrogen | | solubility | DMSO:75.0(Max Conc. mg/mL);133.78(Max Conc. mM)
Water:33.33(Max Conc. mg/mL);59.45(Max Conc. mM)
Ethanol:8.0(Max Conc. mg/mL);14.27(Max Conc. mM) | | form | Solid | | pka | 6.52±0.35(Predicted) | | color | Light yellow to yellow | | InChIKey | NXQKSXLFSAEQCZ-SFHVURJKSA-N | | SMILES | C1(=O)N=C(N2CCN(C(=O)C=C)C[C@@H]2C)C2=CC(F)=C(C3=C(O)C=CC=C3F)N=C2N1C1=C(C)C=CN=C1C(C)C |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | AMG 510 Usage And Synthesis |
| Description | AMG-510 is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. AMG-510 irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. AMG-510 is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors.
| | Biological Activity | AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.
AMG-510, also known as also known as Sotorasib, is a potent KRAS G12C covalent inhibitor and the active atropisomer separated by chiral HPLC. AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells. | | Storage | -20°C, stored under nitrogen
| | In vivo | In immune-competent mice, treatment with AMG 510 resulted in a pro-inflammatory tumour microenvironment and produced durable cures alone as well as in combination with immune-checkpoint inhibitors. Cured mice rejected the growth of isogenic KRASG12D tumours, which suggests adaptive immunity against shared antigens. Reference: Nature. 2019 Nov;575(7781):217-223. https://www.nature.com/articles/s41586-019-1694-1 | | Uses | AMG-510 is a KRAS G12C inhibitor thus leading to the regression of KRAS G12C tumors as it interrupts protein signaling. | | Definition | ChEBI: Sotorasib is a pyridopyrimidine that is pyrido[2,3-d]pyrimidin-2(1H)-one substituted by 4-methyl-2-(propan-2-yl)pyridin-3-yl, (2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl, fluoro and 2-fluoro-6-hydroxyphenyl groups at positions 1, 4, 6 and 7, respectively. It is approved for the treatment of patients with non-small cell lung cancer having KRAS(G12C) mutations. It has a role as an antineoplastic agent. It is a member of acrylamides, a N-acylpiperazine, a pyridopyrimidine, a member of monofluorobenzenes, a member of methylpyridines, a tertiary carboxamide, a tertiary amino compound and a member of phenols. | | in vitro | It was examined whether AMG510 has an antitumor effect on the CACO-2 (human colorectal cancer) cells into which the KRAS G12C (Kirsten rat sarcoma 2 viral oncogene homolog mutation) gene was introduced. The results showed that there was a clear concentration dependent RPR (relative proliferation ratio) decrease and that AMG 510 selectively inhibited KRAS G12C in colon cancer cells in vitro (Fig. 4A). Reference: Mol Clin Oncol. 2021 Jul;15(1):148. | | storage | Store at -20°C |
| | AMG 510 Preparation Products And Raw materials |
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