1346133-11-6
| 中文名称 | 1346133-11-6 |
|---|---|
| 中文同义词 | 化合物 T11909;(S)-3-氟-4-(4-((2-(3-氟苯基)吡咯烷-1-基)甲基)苯氧基)苯甲酰胺;化合物LY2444296;化合物LY2444296,10 MM DMSO 溶液 |
| 英文名称 | (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide |
| 英文同义词 | (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide;LY2444296;FP3FBZ;Benzamide, 3-fluoro-4-[4-[[(2S)-2-(3-fluorophenyl)-1-pyrrolidinyl]methyl]phenoxy]-;3-fluoro-4-(4-{[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]methyl}phenoxy)benzamide;LY2444296, 10 mM in DMSO;Ly2444296 (fp3fbz) |
| CAS号 | 1346133-11-6 |
| 分子式 | C24H22F2N2O2 |
| 分子量 | 408.44 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1346133-11-6.mol |
| 结构式 |  |
1346133-11-6 性质
| 沸点 | 491.6±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.276±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 乙醇：27.5mg/mL（67.33mM）；甲醇：5 mg/mL (12.24 mM) |
| 酸度系数(pKa) | 15.61±0.50(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
| InChIKey | WHHMECUDUQRPJT-QFIPXVFZSA-N |
| SMILES | NC(C1=CC=C(OC2=CC=C(CN3CCC[C@H]3C4=CC=CC(F)=C4)C=C2)C(F)=C1)=O |
LY2444296 是一种有口服生物活性、高亲和力、选择性的短效的 KOPR 拮抗剂，其 Ki 值为 ~1 nM。LY2444296 具有抗焦虑样的作用。
Ki: ~1 nM (KOPR)
LY2444296 displays anti-anxiety like effects in the EPM test.
LY2444296 (3 mg/kg; i.p.; 30 min before U69,593 administration) prevents behavioral and neuroendocrine effects caused by the reference kappa agonist U69,593 in cocaine-naïve rats.
LY2444296 reduces anxiety-like and depressive-like behaviors, as well as CORT release, in rats tested after chronic extended access cocaine self-administration, but not in cocaine-naïve rats.
| Animal Model: | Adult male Sprague Dawley rats (240–250 g) |
| Dosage: | 3 mg/kg |
| Administration: | Injected intraperitoneally; 30 min before U69,593 administration |
| Result: | Prevented behavioral and neuroendocrine effects caused by U69,593 in cocaine-naïve rats. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-135230 | LY2444296 | 1346133-11-6 | 1 mg | 270元 |
| 2025/12/22 | HY-135230 | 1346133-11-6 LY2444296 | 1346133-11-6 | 5mg | 700元 |