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| | METHYL 1-BOC-4-PIPERIDINEACETATE Basic information |
| Product Name: | METHYL 1-BOC-4-PIPERIDINEACETATE | | Synonyms: | Methyl (piperidin-4-yl)acetate, N-BOC protected;N-BOC-4-PIPERIDINEACETIC ACID METHYL ESTER;METHYL 1-BOC-4-PIPERIDINEACETATE;t-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate;Methyl N-Boc-4-piperidineacetate
Methyl 1-Boc-4-piperidineacetate
4-((Methoxycarbonyl)methyl)piperidine-1-carboxylic acid tert-butyl ester;1-Boc-4-Piperidine acetate methyl ester;1-Boc-4-Piperidine acetic acid methyl ester;tert-butyl 4-((methoxycarbonyl)methyl)piperidine-1-carboxylate | | CAS: | 175213-46-4 | | MF: | C13H23NO4 | | MW: | 257.33 | | EINECS: | | | Product Categories: | pharmacetical;Amines;blocks;Carboxes | | Mol File: | 175213-46-4.mol |  |
| | METHYL 1-BOC-4-PIPERIDINEACETATE Chemical Properties |
| Boiling point | 323.1±15.0 °C(Predicted) | | density | 1.062±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | -1.88±0.40(Predicted) | | Appearance | Colorless to light yellow Liquid | | CAS DataBase Reference | 175213-46-4 |
| | METHYL 1-BOC-4-PIPERIDINEACETATE Usage And Synthesis |
| Chemical Properties | White powder | | Uses | Methyl 1-Boc-4-piperidineacetate is used as a pharmaceutical intermediate. It can be used in the preparation of intranasal pharmaceutical compositions of CGRP inhibitors for the treatment of migraine. | | Synthesis | General procedure for the synthesis of methyl N-Boc-4-piperidineacetate from tert-butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate: 1-tert-butoxycarbonyl-4-[(methoxycarbonyl)methylidene]piperidine (875 mg) was dissolved in ethanol (10 mL), to which 10% of palladium-carbon catalyst (~50% water content, 730 mg) was added. The reaction mixture was subjected to catalytic hydrogenation at room temperature and at atmospheric pressure for 3 days. Upon completion of the reaction, the catalyst was removed by filtration and the solvent was subsequently removed by distillation under reduced pressure to afford the target product methyl N-Boc-4-piperidineacetate (871 mg, 99% yield). The product was characterized by 1H-NMR (CDCl3): δ 1.16 (2H, m), 1.45 (9H, s), 1.65 (2H, m), 1.93 (1H, m), 2.25 (2H, d, J = 6.8 Hz), 2.72 (2H, br), 3.68 (3H, s), 4.08 (2H, br). Mass spectrometry (FAB) analysis showed m/z: 258 (M + H)+. | | References | [1] Patent: EP1104754, 2001, A1
[2] Patent: EP1577302, 2005, A1. Location in patent: Page/Page column 121-122
[3] Patent: US2006/94707, 2006, A1. Location in patent: Page/Page column 43
[4] Patent: US2007/259850, 2007, A1. Location in patent: Page/Page column 79
[5] Patent: WO2011/123232, 2011, A1. Location in patent: Page/Page column 9 |
| | METHYL 1-BOC-4-PIPERIDINEACETATE Preparation Products And Raw materials |
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