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| | 1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE Basic information |
| Product Name: | 1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE | | Synonyms: | 1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE;1-Bromo-2,3-difluoro-4-methoxybenzene;4-Bromo-2,3-difluoroanisole;4-Bromo-2,3-difluoroanisole 98%;4-Bromo-2,3-difluoroanisole98%;Benzene, 1-bromo-2,3-difluoro-4-methoxy-;1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE ISO 9001：2015 REACH | | CAS: | 406482-22-2 | | MF: | C7H5BrF2O | | MW: | 223.01 | | EINECS: | 000-000-0 | | Product Categories: | blocks;Bromides | | Mol File: | 406482-22-2.mol |  |
| | 1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE Chemical Properties |
| Melting point | 56-58° | | Boiling point | 203.2±35.0 °C(Predicted) | | density | 1.615 | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | Appearance | White to off-white Solid |
| Hazard Codes | Xi | | Hazard Note | Irritant | | HS Code | 2909309090 |
| | 1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE Usage And Synthesis |
| Synthesis | General procedure: iodomethane (1.56 mL, 25.1 mmol, 1.5 eq.) was slowly added dropwise to a suspension of 2,3-difluoro-4-bromophenol (3.5 g, 16.7 mmol) and potassium carbonate (2.77 g, 20.0 mmol, 1.2 eq.) in N,N-dimethylformamide (30 mL). The reaction mixture was stirred at room temperature for 3 days. After completion of the reaction, the insoluble precipitate was removed by filtration. The filtrate was concentrated to dryness under reduced pressure. Dichloromethane and water were added to the residue and the product was extracted with dichloromethane. The organic phases were combined, dried over anhydrous magnesium sulfate and subsequently concentrated under reduced pressure to afford 4-bromo-2,3-difluoroanisole as a white crystalline solid (3.8 g, quantitative yield). | | References | [1] Patent: WO2012/175991, 2012, A1. Location in patent: Page/Page column 78 |
| | 1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE Preparation Products And Raw materials |
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