ABT-418 HYDROCHLORIDE manufacturers
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| | ABT-418 HYDROCHLORIDE Basic information |
| Product Name: | ABT-418 HYDROCHLORIDE | | Synonyms: | ABT-418 HCl;(S)-3-Methyl-5-(1-methylpyrrolidin-2-yl)-isoxazolea€￠HCl;ABT-418 HYDROCHLORIDE;3-Methyl-5-[(2S)-1-Methylpyrrolidin-2-yl]isoxazole hydrochloride;ABT418 hydrochloride,ABT 418 hydrochloride;3-Methyl-5-[(2S)-1-Methyl-2-Pyrrolidinyl]-1,2-Oxazole Hydrochloride | | CAS: | 147388-83-8 | | MF: | C9H14N2O.ClH | | MW: | 202.684 | | EINECS: | | | Product Categories: | | | Mol File: | 147388-83-8.mol |  |
| | ABT-418 HYDROCHLORIDE Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: 15 mg/mL, soluble | | form | solid | | color | white to off-white | | Water Solubility | H2O: soluble 15mg/mL | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. | | InChI | 1S/C9H14N2O.ClH/c1-7-6-9(12-10-7)8-4-3-5-11(8)2;/h6,8H,3-5H2,1-2H3;1H/t8-;/m0./s1 | | InChIKey | VOXHERKWAIEJQF-QRPNPIFTSA-N | | SMILES | Cl.CN1CCC[C@H]1c2cc(C)no2 |
| Hazard Codes | T+ | | Risk Statements | 26/27/28 | | Safety Statements | 22-28-36/37-45-7/9 | | RIDADR | UN 2811 6.1/PG 1 | | WGK Germany | 3 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Dermal
Acute Tox. 2 Inhalation
Acute Tox. 2 Oral |
| | ABT-418 HYDROCHLORIDE Usage And Synthesis |
| Description | ABT-418 (CAS 147388-83-8) is an agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1 Displays anxiolytic activity in a rat model and was 6-fold more potent than diazepam.2 Reduces distractibility in a primate model3 and may have relevance in attention deficit hyperactivity disorder4. Improves cognition in Alzheimer’s disease patients.5 | | Uses | ABT-418 Hydrochloride is a neuronal nicotinic acetylcholine receptor agonist or activator which can be synthesized from L-proline. | | in vivo | ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze[1].
Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment[1].
ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD[2].
ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression[2].
| Animal Model: | Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model[2] | | Dosage: | 0.6 mg/kg | | Administration: | Intraperitoneal injection; once daily; for two weeks | | Result: | Effectively improved spatial memory. |
| | References | [1] R L PAPKE. Activation and inhibition of rat neuronal nicotinic receptors by ABT-418.[J]. British Journal of Pharmacology, 1997, 120 3: 429-438. DOI:10.1038/sj.bjp.0700930
[2] J D BRIONI. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.[J]. Journal of Pharmacology and Experimental Therapeutics, 1994, 271 1: 353-361.
[3] M A PRENDERGAST. Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys.[J]. Psychopharmacology, 1998, 136 1: 50-58. DOI:10.1007/s002130050538
[4] J BIEDERMAN T S. Non-stimulant treatments for ADHD.[J]. European Child & Adolescent Psychiatry, 2000, 9 Suppl 1: I51-9. DOI:10.1007/s007870070019
[5] A POTTER. Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer’s disease.[J]. Psychopharmacology, 1999, 142 4: 334-342. DOI:10.1007/s002130050897 |
| | ABT-418 HYDROCHLORIDE Preparation Products And Raw materials |
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