DAPH

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DAPH Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:CGP52411
CAS:145915-58-8
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:CGP52411
CAS:145915-58-8
Purity:99.56% Package:1mg;39USD|5mg;97USD|10mg;157USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:CGP52411
CAS:145915-58-8
Purity:99.56% Package:1mg;39USD|5mg;97USD|10mg;157USD
Company Name: NANJING YINGWEN BIOTECHNOLOGY CO LTD
Tel: +8613382787392
Email: sales@aeechem.com
Products Intro: CAS:145915-58-8
Purity:98%
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:CGP 52411;5,6-Bis(phenylaMino)-1H-isoindole-1,3(2H)-dione
CAS:145915-58-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g

DAPH manufacturers

  • CGP52411
  • CGP52411 pictures
  • $35.00 / 1mg
  • 2026-05-11
  • CAS:145915-58-8
  • Min. Order:
  • Purity: 99.78%
  • Supply Ability: 10g
  • CGP52411
  • CGP52411 pictures
  • $35.00 / 1mg
  • 2026-04-22
  • CAS:145915-58-8
  • Min. Order:
  • Purity: 99.78%
  • Supply Ability: 10g
DAPH Basic information
Product Name:DAPH
Synonyms:DAPH-1 (DAPH;DAPH/CGP 52411;4,5-Dianilinophthalimide, 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione, CGP 52411;1H-Isoindole-1,3(2H)-dione, 5,6-bis(phenylamino)-;DAPH >=98% (HPLC), solid;CGP52411, 10 mM in DMSO
CAS:145915-58-8
MF:C20H15N3O2
MW:329.35
EINECS:406-050-3
Product Categories:
Mol File:145915-58-8.mol
DAPH Structure
DAPH Chemical Properties
Melting point 199-202℃
density 1.374
storage temp. 2-8°C
solubility DMSO: ~30 mg/mL
pka9.06±0.20(Predicted)
form solid
color orange
InChI1S/C20H15N3O2/c24-19-15-11-17(21-13-7-3-1-4-8-13)18(12-16(15)20(25)23-19)22-14-9-5-2-6-10-14/h1-12,21-22H,(H,23,24,25)
InChIKeyAAALVYBICLMAMA-UHFFFAOYSA-N
SMILESO=C1NC(=O)c2cc(Nc3ccccc3)c(Nc4ccccc4)cc12
Safety Information
Safety Statements 36/37
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
DAPH Usage And Synthesis
UsesCGP 52411 is a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitmuor activity. It may offer therapeutic agents for the treatment of hyperproliferative diseases.
DefinitionChEBI: 4,5-dianilinophthalimide is phthalimide substituted at the 4- and 5-positions by anilino groups. It has a role as a tyrosine kinase inhibitor and a geroprotector.
Biochem/physiol ActionsDAPH is an inhibitor of Aβ fibril formation; Protein tyrosine kinase inhibitor, specific for EGFR.
in vivo

CGP52411 (3.2 mg/kg, 6.3 mg/kg, 12.5 mg/kg, 25 mg/kg, and 50 mg/kg; oral administration; daily; for 15 days; female BALB/c nude mice) treatment in vivo against xenografts of the A431 and SK-OV-3 tumors, and has antitumor activity[1].

Animal Model:Female BALB/c nude mice injected with A431cells[1]
Dosage:3.2 mg/kg, 6.3 mg/kg, 12.5 mg/kg, 25 mg/kg, and 50 mg/kg
Administration:Oral administration; daily; for 15 days
Result:Antitumor efficacy was obtained at doses between 50 mg/kg and 6.3 mg/kg.
IC 50EGFR: 0.3 μM (IC50); Amyloid-β
DAPH Preparation Products And Raw materials
Tag:DAPH(145915-58-8) Related Product Information
TYRPHOSTIN B48 2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- 4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE PD168393 TYRPHOSTIN A51 AG 213 CIVENTICHEM CV-409 AG 1478 HYDROCHLORIDE AG 18 LAVENDUSTIN A METHYL 2,5-DIHYDROXYCINNAMATE H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH AG 825 TYRPHOSTIN A25 Canertinib