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| | 2 6-DICHLOROPYRIDINE-3-CARBOXALDEHYDE Basic information |
| Product Name: | 2 6-DICHLOROPYRIDINE-3-CARBOXALDEHYDE | | Synonyms: | CML-018;2,6-Dichloro-3-pyridinecarbaldehyde;2,6-Dichloropyridin-3-carboxaldehyde;3-Pyridinecarboxaldehyde,2,6-dichloro-(;2,6-Dichloropyridine-3-carboxaldehyde,2,6-Dichloronicotinaldehyde;2,6-Dichloropyridine-3-ca...;2,6-Dichloropyridine-3-carboxaldehyde 97%;2,6- twochlorine sMokealdehyde | | CAS: | 55304-73-9 | | MF: | C6H3Cl2NO | | MW: | 176 | | EINECS: | | | Product Categories: | Alcohols and Derivatives;Heterocycles;Heterocycle-Pyridine series;pharmacetical;Pyridine;Aldehyde;Building Blocks | | Mol File: | 55304-73-9.mol |  |
| | 2 6-DICHLOROPYRIDINE-3-CARBOXALDEHYDE Chemical Properties |
| Melting point | 74-75 °C (lit.) | | Boiling point | 95°C/3mmHg(lit.) | | density | 1.488±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | powder to crystal | | pka | -4.52±0.10(Predicted) | | color | White to Orange to Green | | InChI | InChI=1S/C6H3Cl2NO/c7-5-2-1-4(3-10)6(8)9-5/h1-3H | | InChIKey | HWTMRGXKSANEDO-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC(Cl)=CC=C1C=O |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38-43 | | Safety Statements | 26-36/37 | | RIDADR | 2811 | | WGK Germany | 3 | | HazardClass | IRRITANT | | PackingGroup | Ⅲ | | HS Code | 2933399990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| | 2 6-DICHLOROPYRIDINE-3-CARBOXALDEHYDE Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2,6-dichloro-3-pyridinecarboxaldehyde from 2,6-dichloro-3-hydroxymethylpyridine was as follows: to a solution of (2,6-dichloropyridin-3-yl)methanol (1.0 g, 5.62 mmol) in dichloromethane (10 ml) was added Dess-Martin reagent (4.8 g, 11.24 mmol) at 26 °C. After addition, the reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched by addition of 5% Na2S2O3 aqueous solution and stirring was continued for 30 min. The reaction mixture was extracted with dichloromethane (2 x 30 ml). The organic layers were combined and washed sequentially with saturated Na2S2O3 solution (50 ml), brine (30 ml), dried over anhydrous Na2SO4, and concentrated under reduced pressure to afford the crude 2,6-dichloro-3-pyridinecarboxaldehyde (800 mg, 80% yield), which was used directly in the next step of the reaction. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 10.38 (s, 1H), 8.19 (d, J = 8.0Hz, 1H), 7.44 (d, J = 8.0Hz, 1H). | | References | [1] Patent: WO2014/100695, 2014, A1. Location in patent: Paragraph 00409
[2] Journal of Organic Chemistry, 1982, vol. 47, # 14, p. 2800 - 2802
[3] Patent: WO2006/44454, 2006, A1. Location in patent: Page/Page column 62
[4] Patent: US3974166, 1976, A |
| | 2 6-DICHLOROPYRIDINE-3-CARBOXALDEHYDE Preparation Products And Raw materials |
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