| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:PROTAC ERα Degrader-2
CAS:1351169-29-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
|
| Tel: |
010-60605840 15801484223; |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:PROTAC ERα Degrader-2
CAS:1351169-29-3
Purity:98% Package:5mg;10mg;25mg;50mg
|
| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
|
| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:PROTAC ERα Degrader-2
CAS:1351169-29-3
Purity:98%+HPLC Package:10mg，100mg，500mg，1g，2g，5g，10g，More
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| | PROTAC ER Degrader-2 Basic information |
| Product Name: | PROTAC ER Degrader-2 | | Synonyms: | PROTAC ER Degrader-2;Benzenebutanamide, β-amino-α-hydroxy-N-[(1S)-14-[[(E)-(3-hydroxyestra-1,3,5(10)-trien-17-ylidene)amino]oxy]-1-(2-methylpropyl)-2,13-dioxo-6,9-dioxa-3,12-diazatetradec-1-yl]-, (αS,βR)-;PROTAC ERα Degrader-2 | | CAS: | 1351169-29-3 | | MF: | C42H61N5O8 | | MW: | 763.98 | | EINECS: | | | Product Categories: | | | Mol File: | 1351169-29-3.mol |  |
| | PROTAC ER Degrader-2 Chemical Properties |
| density | 1.29±0.1 g/cm3(Predicted) | | form | Solid | | pka | 10.24±0.40(Predicted) | | color | White to off-white |
| | PROTAC ER Degrader-2 Usage And Synthesis |
| Uses | PROTAC ERα Degrader-2 comprises a IAP ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1]. | | IC 50 | ERα; cIAP1 | | References | [1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176. DOI:10.1016/j.csbj.2019.01.006 |
| | PROTAC ER Degrader-2 Preparation Products And Raw materials |
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