| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
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| | Pomalidomide-PEG6-butyl amine hydrochloride Basic information |
| | Pomalidomide-PEG6-butyl amine hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | form | powder or crystals |
| | Pomalidomide-PEG6-butyl amine hydrochloride Usage And Synthesis |
| Uses | Partial PROTAC Pomalidomide-PEG6-butyl amine (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other Partial PROTACs with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. | | reaction suitability | reactivity: carboxyl reactive
reagent type: ligand-linker conjugate |
| | Pomalidomide-PEG6-butyl amine hydrochloride Preparation Products And Raw materials |
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