Octadecanedioic acid, 1-(1,1-dimethylethyl) 18-(2,5-dioxo-1-pyrrolidinyl) ester manufacturers
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| | Octadecanedioic acid, 1-(1,1-dimethylethyl) 18-(2,5-dioxo-1-pyrrolidinyl) ester Basic information |
| Product Name: | Octadecanedioic acid, 1-(1,1-dimethylethyl) 18-(2,5-dioxo-1-pyrrolidinyl) ester | | Synonyms: | Octadecanedioic acid, 1-(1,1-dimethylethyl) 18-(2,5-dioxo-1-pyrrolidinyl) ester;Boc-C16-NHS ester;t-butyl-octadecanedioate-NHS ester;1-tert-Butyl 18-(2,5-dioxopyrrolidin-1-yl) octadecanedioate;SemaglutideImpurity7;1-tert-Butyl 18-(2,5-Dioxo-1-pyrrolidinyl) Octadecanedioate;1-(1,1-dimethylethyl) 18-(2,5-dioxo-1-pyrrolidinyl) ester;Octadecanedioic acid, 1-(1,1-dimethylethyl) 18-(2,5-dioxo-1-pyrrolidinyl) ester（Boc-C16-NHS ester ） | | CAS: | 843666-34-2 | | MF: | C26H45NO6 | | MW: | 467.64 | | EINECS: | | | Product Categories: | | | Mol File: | 843666-34-2.mol |  |
| | Octadecanedioic acid, 1-(1,1-dimethylethyl) 18-(2,5-dioxo-1-pyrrolidinyl) ester Chemical Properties |
| Boiling point | 537.7±42.0 °C(Predicted) | | density | 1.05±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | Solid | | color | White to off-white | | InChI | InChI=1S/C26H45NO6/c1-26(2,3)32-24(30)18-16-14-12-10-8-6-4-5-7-9-11-13-15-17-19-25(31)33-27-22(28)20-21-23(27)29/h4-21H2,1-3H3 | | InChIKey | JTOVMMPSILRQQJ-UHFFFAOYSA-N | | SMILES | C(OC(C)(C)C)(=O)CCCCCCCCCCCCCCCCC(ON1C(=O)CCC1=O)=O |
| | Octadecanedioic acid, 1-(1,1-dimethylethyl) 18-(2,5-dioxo-1-pyrrolidinyl) ester Usage And Synthesis |
| Description | t-butyl-octadecanedioate-NHS ester has a t-butyl ester group and an NHS ester moiety. The t-butyl group can be deprotected under acidic conditions. NHS ester can react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. | | Uses | Boc-C16-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Octadecanedioic acid, 1-(1,1-dimethylethyl) 18-(2,5-dioxo-1-pyrrolidinyl) ester Preparation Products And Raw materials |
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