FLT3-IN-3 manufacturers
- FLT3-IN-3
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- $109.00
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2026-07-27
- CAS:2229050-90-0
- Purity: 99.97%
- Supply Ability: 10g
- FLT3-IN-3
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- $109.00
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2026-07-14
- CAS:2229050-90-0
- Purity: 99.97%
- Supply Ability: 10g
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| | FLT3-IN-3 Basic information |
| Product Name: | FLT3-IN-3 | | Synonyms: | FLT3-IN-3;9H-Purine-2,6-diamine, N2-(trans-4-aminocyclohexyl)-9-cyclopentyl-N6-[4-(4-morpholinylmethyl)phenyl]-;SAN50900;inhibit,Fms like tyrosine kinase 3,FLT-3-IN-3,FLT3,CD135,Inhibitor,Cluster of differentiation antigen 135,FLT3IN3,FLT3 IN 3;N2-(trans-4-Aminocyclohexyl)-9-cyclopentyl-N6-(4-(morpholinomethyl)phenyl)-9H-purine-2,6-diamine;9-cyclopentyl-N6-{4-[(morpholin-4-yl)methyl]phenyl}-N2-[(1r,4r)-4-aminocyclohexyl]-9H-purine-2,6-diamine;FLT3-IN-3, 10 mM in DMSO | | CAS: | 2229050-90-0 | | MF: | C27H38N8O | | MW: | 490.64 | | EINECS: | | | Product Categories: | | | Mol File: | 2229050-90-0.mol |  |
| | FLT3-IN-3 Chemical Properties |
| Melting point | 133-135 °C | | Boiling point | 717.6±70.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml; PBS (pH 7.2): insol | | form | A solid | | pka | 10.42±0.70(Predicted) | | color | White to off-white |
| | FLT3-IN-3 Usage And Synthesis |
| Uses | FLT3-IN-3 is a potent FLT3 inhibitor with IC50s of 13 and 8 nM for FLT3 WT and FLT3 D835Y, respectively. | | in vivo | A single dose of FLT3-IN-3 (Compound 7d; 10 mg/kg; i.p.) in mice with subcutaneous MV4-11 xenografts causes sustained inhibition of FLT3 and STAT5 phosphorylation over 48 hours[1]. | Animal Model: | Female athymic nu/nu mice with subcutaneously implanted MV4-11 xenografts[1] | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal (i.p.) injection; 48 hours | | Result: | Effectively inhibited FLT3-ITD autophosphorylation in MV4-11 xenografts. |
| | References | [1] Gucky T, et al. Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl- N6-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations. J Med Chem. 2018 May 10;61(9):3855-3869. DOI:10.1021/acs.jmedchem.7b01529 |
| | FLT3-IN-3 Preparation Products And Raw materials |
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