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| | EAPP (1E4) Mouse mAb Chemical Properties |
| | EAPP (1E4) Mouse mAb Usage And Synthesis |
| Source | Mouse | | Reactivity | Human;Mouse;Rat;Monkey | | Background | Regulation of the E2F family of transcription factors, primarily through the retinoblastoma protein, is vital for control of cell proliferation and cell death. E2F-associated phosphoprotein was identified as an E2F-family binding protein that modulates E2F-regulated transcription and may be required for S phase entry. EAPP is expressed at varied levels in all tissues and cell types examined and its expression is reduced in nocodazole-arrested cells. Mass spectrometry studies have identified multiple EAPP phosphorylation sites including Ser109 and Ser111, but biological consequences of EAPP phosphorylation have yet to be elucidated. | | References | [1] Polager, S. and Ginsberg, D. (2008) Trends Cell Biol 18, 528-35.
[2] Novy, M. et al. (2005) Mol Biol Cell 16, 2181-90.
[3] Dephoure, N. et al. (2008) Proc Natl Acad Sci U S A 105, 10762-7.
[4] Mayya, V. et al. (2009) Sci Signal 2, ra46.
[5] Olsen, J.V. et al. (2006) Cell 127, 635-48. |
| | EAPP (1E4) Mouse mAb Preparation Products And Raw materials |
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