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| | PAX2 antibody Chemical Properties |
| | PAX2 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat | | Background | Paired box proteins are a family of transcription factors that play important and diverse roles in animal development. Nine PAX proteins have been described in humans and other mammals. They are defined by the presence of an amino-terminal "paired" domain, consisting of two helix-turn-helix motifs, with DNA binding activity. PAX proteins are classified into four structurally distinct subgroups based on the absence or presence of a carboxy-terminal homeodomain and a central octapeptide region. Subgroup I contains the octapeptide but lacks the homeodomain; subgroup II contains the octapeptide and a truncated homeodomain; subgroup III contains the octapeptide and a complete homeodomain; and subgroup IV contains a complete homeodomain but lacks the octapeptide region. PAX proteins play critically important roles in development by regulating transcriptional networks responsible for embryonic patterning and organogenesis; a subset of PAX proteins also maintain functional importance during postnatal development. Research studies have implicated genetic mutations that result in aberrant expression of PAX genes in a number of cancer subtypes, with members of subgroups II and III identified as potential mediators of tumor progression.PAX2 is involved in the development of the nervous and excretory systems including the kidney and urogentical tract, the optic stalk, ear, midbrain-hindbrain junction, and the spinal cord. | | References | [1] Lang, D. et al. (2007) Biochem Pharmacol 73, 1-14.
[2] Robson, E.J. et al. (2006) Nat Rev Cancer 6, 52-62.
[3] Wang, Q. et al. (2008) J Cell Mol Med 12, 2281-94.
[4] Blake, J.A. et al. (2008) Dev Dyn 237, 2791-803.
[5] Schedl, A. and Hastie, N.D. (2000) Curr Opin Genet Dev 10, 543-9.
[6] Torres, M. et al. (1995) Development 121, 4057-65. |
| | PAX2 antibody Preparation Products And Raw materials |
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