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| | PCNA (PC10) Mouse mAb Chemical Properties |
| | PCNA (PC10) Mouse mAb Usage And Synthesis |
| Source | Mouse | | Reactivity | Human;Mouse;Rat;Monkey;Bovine;Pig | | Background | Proliferating cell nuclear antigen is a member of the DNA sliding clamp family of proteins that assist in DNA replication. Crystal structure data suggests that a PCNA homotrimer ring can encircle and slide along the DNA double helix. Multiple proteins involved in DNA replication, DNA repair, and cell cycle control bind to PCNA rather than directly associating with DNA, thus facilitating fast processing of DNA. PCNA protein expression is a well-accepted marker of proliferation. | | References | [1] Kelman, Z. and O'Donnell, M. (1995) Nucleic Acids Res 23, 3613-20.
[2] Krishna, T.S. et al. (1994) Cell 79, 1233-43.
[3] Maga, G. and Hubscher, U. (2003) J Cell Sci 116, 3051-60.
[4] Sawey, E.T. et al. (2011) Cancer Cell 19, 347-58. |
| | PCNA (PC10) Mouse mAb Preparation Products And Raw materials |
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