| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Email: |
3003867561@qq.com |
| Products Intro: |
Product Name:CDK4/6-IN-3
CAS:2366237-37-6
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:CDK4/6-IN-3
CAS:2366237-37-6
Package:100mg/RMB 46500;50mg/RMB 36800;25mg/RMB 28800
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| | CDK4/6-IN-3 Basic information |
| Product Name: | CDK4/6-IN-3 | | Synonyms: | CDK4/6-IN-3;2-Pyrimidinamine, N-[5-(6-ethyl-2,6-diazaspiro[3.3]hept-2-yl)-2-pyridinyl]-5-fluoro-4-[(4R)-5,6,7,8-tetrahydro-4-methyl-4H-pyrazolo[1,5-a]azepin-3-yl]-;CDK4/6 IN 3,CDK-4/6-IN-3,CDK4/6IN3 | | CAS: | 2366237-37-6 | | MF: | C25H31FN8 | | MW: | 462.57 | | EINECS: | | | Product Categories: | | | Mol File: | 2366237-37-6.mol |  |
| | CDK4/6-IN-3 Chemical Properties |
| Boiling point | 681.1±65.0 °C(Predicted) | | density | 1.41±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 9.13±0.20(Predicted) |
| | CDK4/6-IN-3 Usage And Synthesis |
| Uses | CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of <0.3 nM and 2.2 nM, respectively. CDK4/6-IN-3 inhibits CDK1 with a Ki of 110 nM. CDK4/6-IN-3 can be used for the treatment of glioblastoma[1]. | | IC 50 | CDK4: 0.3 nM (Ki); CDK6: 2.2 nM (Ki); CDK1: 110 nM (Ki) | | References | [1] Bronner SM, et al. Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2294-2301. DOI:10.1016/j.bmcl.2019.06.021 |
| | CDK4/6-IN-3 Preparation Products And Raw materials |
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