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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136 |
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| Products Intro: |
Product Name:LysRs-IN-2
CAS:2170696-76-9
Purity:98% Package:50MG;100MG,1G,5G,100G
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LysRs-IN-2 manufacturers
- LysRs-IN-2
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- $1530.00 / 100mg
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2025-06-01
- CAS:2170696-76-9
- Min. Order:
- Purity: 99.34%
- Supply Ability: 10g
- LysRs-IN-2
-
- $1530.00 / 100mg
-
2025-04-30
- CAS:2170696-76-9
- Min. Order:
- Purity: 99.34%
- Supply Ability: 10g
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| | LysRs-IN-2 Basic information |
| Product Name: | LysRs-IN-2 | | Synonyms: | LysRs-IN-2;LysRs inhibitor 2;4H-1-Benzopyran-2-carboxamide, N-[(4,4-difluoro-1-hydroxycyclohexyl)methyl]-6-fluoro-4-oxo-;LysRsIN2,LysRs IN 2 | | CAS: | 2170696-76-9 | | MF: | C17H16F3NO4 | | MW: | 355.31 | | EINECS: | | | Product Categories: | | | Mol File: | 2170696-76-9.mol |  |
| | LysRs-IN-2 Chemical Properties |
| Boiling point | 531.1±50.0 °C(Predicted) | | density | 1.44±0.1 g/cm3(Predicted) | | storage temp. | 4°C, stored under nitrogen | | solubility | DMSO : ≥ 60 mg/mL (168.87 mM) | | pka | 13.42±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | LysRs-IN-2 Usage And Synthesis |
| Uses | LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.015 μM and 0.13 μM for Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) and Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS), respectively[1]. | | in vivo | LysRs-IN-2 (1.5 mg/kg; orally once a day for 4 days) reduces parasitemia by 90% in the murine P. falciparum SCID model. LysRs-IN-2 (20 mg/kg; orally once a day for 7 days) reduces parasite shedding in NOD SCID gamma mice and INF-γ-knockout mice (Cryptosporidium mouse models)[1]. | Animal Model: | Murine P. falciparum NODscidIL2Rγnull (SCID) model[1] | | Dosage: | 1.5 mg/kg | | Administration: | Orally once a day for 4 days | | Result: | Reduced parasitemia by 90% in the malaria SCID mouse model. |
| Animal Model: | NOD SCID gamma and INF-γ–knockout mouse models (Cryptosporidium mouse models)[1] | | Dosage: | 20 mg/kg | | Administration: | Orally once a day for 7 days | | Result: | Reduced parasite shedding below detection level, and this reduction was sustained for 3 wk after treatment had stopped in INF-γ-knockout mice.
Dosed orally at a concentration of 20 mg/kg once a day for 7 days showed 96% reduction of parasite shedding comparable to paromomycin in NOD SCID gamma mice. |
| | References | [1] Baraga?a B, et al. Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020. DOI:10.1073/pnas.1814685116 |
| | LysRs-IN-2 Preparation Products And Raw materials |
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