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| | Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln Basic information |
| | Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln Chemical Properties |
| Boiling point | 1220.2±65.0 °C(Predicted) | | density | 1.267±0.06 g/cm3(Predicted) | | pka | 3.25±0.10(Predicted) | | form | Solid | | color | White to off-white | | Sequence | Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln |
| | Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln Usage And Synthesis |
| Uses | GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT)[1][2][3]. | | Biological Activity | Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln（GPLGIAGQ）, an MMP2 cleavable polypeptide, has been used as a stimulus-sensitive linker in both liposomes and micellar nanocarriers for MMP2-triggered tumor targeting studies. GPLGIAGQ can be used to synthesize unique MMP2-targeted photosensitizers in photodynamic therapy (PDT). | | in vitro | GPLGIAGQ is used to trigger PEG deshielding of liposomal carriers, resulting in enhanced cellular internalization. | | References | [1] Hou W, et al. MMP2-Targeting and Redox-Responsive PEGylated Chlorin e6 Nanoparticles for Cancer Near-Infrared Imaging and Photodynamic Therapy. ACS Appl Mater Interfaces. 2016 Jan 20;8(2):1447-57. DOI:10.1021/acsami.5b10772
[2] Zhu L, et al. Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs. Biomaterials. 2014 Apr;35(13):4213-22. DOI:10.1016/j.biomaterials.2014.01.060
[3] Liu FH, et al. Enzyme-sensitive cytotoxic peptide-dendrimer conjugates enhance cell apoptosis and deep tumor penetration. Biomater Sci. 2018 Feb 27;6(3):604-613. DOI:10.1039/c7bm01182b |
| | Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln Preparation Products And Raw materials |
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