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BOC Sciences |
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
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| | Photoswitchable PAD Inhibitor (technical grade) Basic information |
| Product Name: | Photoswitchable PAD Inhibitor (technical grade) | | Synonyms: | Photoswitchable PAD Inhibitor (technical grade);Benzamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-4-(2-phenyldiazenyl)-;N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-4-(2-phenyldiazenyl)-benzamide | | CAS: | 2226393-62-8 | | MF: | C26H26ClN7O | | MW: | 487.98 | | EINECS: | | | Product Categories: | | | Mol File: | 2226393-62-8.mol |  |
| | Photoswitchable PAD Inhibitor (technical grade) Chemical Properties |
| density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Methanol: 30 mg/ml | | form | A crystalline solid | | pka | 11.40±0.10(Predicted) |
| | Photoswitchable PAD Inhibitor (technical grade) Usage And Synthesis |
| Description | Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity. Without photoactivation, it is a weak inhibitor of PAD2 and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro. It does not inhibit histone H3 citrullination in HEK293T cells overexpressing PAD2. However, it can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination. |
| | Photoswitchable PAD Inhibitor (technical grade) Preparation Products And Raw materials |
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