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| | 2-ETHOXY-MALONIC ACID DIETHYL ESTER Basic information |
| Product Name: | 2-ETHOXY-MALONIC ACID DIETHYL ESTER | | Synonyms: | 2-ETHOXY-MALONIC ACID DIETHYL ESTER;ethoxy-malonic acid diethyl ester;diethyl 2-ethoxymalonate;Diethyl ethoxymalonate;Ethoxypropanedioic acid diethyl ester;1,3-diethyl 2-ethoxypropanedioate;2-Hydroxydiethyl Malonate;Propanedioic acid, 2-ethoxy-, 1,3-diethyl ester | | CAS: | 37555-99-0 | | MF: | C9H16O5 | | MW: | 204.22 | | EINECS: | | | Product Categories: | | | Mol File: | 37555-99-0.mol |  |
| | 2-ETHOXY-MALONIC ACID DIETHYL ESTER Chemical Properties |
| Boiling point | 261℃ | | density | 1.070 | | Fp | 108℃ | | storage temp. | Sealed in dry,Room Temperature | | pka | 13.29±0.46(Predicted) | | Appearance | Colorless to light yellow Liquid |
| | 2-ETHOXY-MALONIC ACID DIETHYL ESTER Usage And Synthesis |
| Synthesis | Example 1: Scheme 4
Preparation of diethyl 2-ethoxy-malonate
A mixture of diethyl oxalate (39.23 ml, 1.12 eq.) and ethyl 2-ethoxyacetate (34.95 ml, 1 eq.) was added dropwise to a slurry of sodium ethanolate (18.64 g, 1.07 eq.) in toluene (100 ml) at 45-50 °C. After the dropwise addition was completed, the reaction mixture was heated to 70-80°C and maintained for 2 hours. After completion of the reaction, the mixture was cooled and poured into 70 ml of 14% hydrochloric acid solution. The resulting mixture was extracted with ethyl acetate (EA), the organic layers were combined and washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 55.86 g (93.7% yield) of the target product diethyl 2-ethoxy-malonate. | | References | [1] Patent: WO2011/80568, 2011, A2. Location in patent: Page/Page column 47-48 |
| | 2-ETHOXY-MALONIC ACID DIETHYL ESTER Preparation Products And Raw materials |
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