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| | 3-Methyl-4-nitroaniline Basic information |
| | 3-Methyl-4-nitroaniline Chemical Properties |
| Melting point | 136-137°C | | Boiling point | 330.0±22.0 °C(Predicted) | | density | 1.269±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Methanol | | form | Solid | | pka | 1.12±0.10(Predicted) | | color | Brown Crystalline | | BRN | 2209112 | | CAS DataBase Reference | 611-05-2(CAS DataBase Reference) |
| | 3-Methyl-4-nitroaniline Usage And Synthesis |
| Chemical Properties | Brown Crystalline Solid | | Uses | 3-Methyl-4-nitrobenzeneamine (cas# 611-05-2) is a compound useful in organic synthesis. | | Synthesis Reference(s) | Synthetic Communications, 18, p. 2161, 1988 DOI: 10.1080/00397918808068287 | | Synthesis | General procedure for the synthesis of 3-methyl-4-nitroaniline (20-2) from 3-methyl-4-nitrobenzamide (20-1, 40 g, 222 mmol): 20-1 was dissolved in 400 mL of methanol/water (v/v=1/1) mixed solvent and cooled to 0 °C. Subsequently, sodium hydroxide (35.6 g, 888 mmol) was added to the solution and stirred for 0.5 hours. Sodium hypochlorite solution (380 g, 556 mmol) was added slowly and dropwise at 0°C. The reaction mixture was gradually warmed up to room temperature (20°C) and stirring was continued for 18 hours. After that, the mixture was further warmed up to 35°C and stirred for 1 hour, then warmed up to 75°C and stirred for 0.5 hours. After completion of the reaction, the mixture was cooled to room temperature. The pH was adjusted to 6.0 with hydrochloric acid, at which time a brown precipitate was produced. The precipitate was collected by filtration and washed twice with 200 mL of water to give the final 20-2 (29 g, 86% yield) as a tan powder. | | References | [1] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 297 |
| | 3-Methyl-4-nitroaniline Preparation Products And Raw materials |
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