- TAME hydrochloride
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- $30.00 / 25mg
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2026-01-13
- CAS:1784-03-8
- Min. Order:
- Purity: 99.21%
- Supply Ability: 10g
- Tos-Arg-OMe·HCl
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- $1.10 / 1g
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2025-06-25
- CAS:1784-03-8
- Min. Order: 1g
- Purity: 99.0% min
- Supply Ability: 100 tons min
- TOS-ARG-OME HCL
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- $1.00 / 1KG
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2019-07-06
- CAS:1784-03-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20kg
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| | TOS-ARG-OME HCL Basic information |
| | TOS-ARG-OME HCL Chemical Properties |
| Melting point | 145-147(lit.) | | alpha | -14 º (c=4, H2O) | | refractive index | -14 ° (C=4, H2O) | | storage temp. | -20°C | | solubility | methanol: 50 mg/mL, clear, colorless | | form | Fine Crystalline Powder | | color | White | | BRN | 3922357 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. | | InChI | 1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1 | | InChIKey | JIQFFACVQXXHMY-YDALLXLXSA-N | | SMILES | Cl.COC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccc(C)cc1 | | CAS DataBase Reference | 1784-03-8(CAS DataBase Reference) |
| | TOS-ARG-OME HCL Usage And Synthesis |
| Description | TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2 | | Chemical Properties | white fine crystalline powder | | Uses | enzyme inhibitor | | Uses | Substrate for trypsin, thrombin, plasmin and other proteases. | | Uses | N-4-Tosyl-L-arginine Methyl Ester Hydrochloride acts as a synthetic substrate of serine proteases and thus is used to determine serine proteases from diverse organic sources. | | Biochem/physiol Actions | Nα-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1. | | References | [1] XING ZENG. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.[J]. Cancer Cell, 2010, 18 4: 382-395. DOI:10.1016/j.ccr.2010.08.010
[2] XING ZENG Randall W K. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination[J]. Nature chemical biology, 2012, 8 4: 383-392. DOI:10.1038/nchembio.801 |
| | TOS-ARG-OME HCL Preparation Products And Raw materials |
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