| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
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| | 4-Cyano-3-methylisoquinoline Basic information |
| | 4-Cyano-3-methylisoquinoline Chemical Properties |
| Boiling point | 330.9±22.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (50mg/ml) | | form | solid | | pka | 2.26±0.31(Predicted) | | color | white | | InChI | 1S/C11H8N2/c1-8-11(6-12)10-5-3-2-4-9(10)7-13-8/h2-5,7H,1H3 | | InChIKey | SZWLGBJCLZDZBY-UHFFFAOYSA-N | | SMILES | n1cc2c(c(c1C)C#N)cccc2 |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | 4-Cyano-3-methylisoquinoline Usage And Synthesis |
| Uses | 4-Cyano-3-methylisoquinoline is an inhibitor for protein kinase A (PKA) with an IC50 of micromolar level. 4-Cyano-3-methylisoquinoline reverses morphine tolerance in mouse model[1]. | | Definition | ChEBI: 3-methyl-4-isoquinolinecarbonitrile is a member of isoquinolines. | | Biological Activity | Cell permeable: yes', 'Primary Target
PKA', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 30 nM against protein kinase A | | storage | +4°C | | References | [1] Smith FL, et al., The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA. Brain Res. 2003 Sep 19;985(1):78-88. DOI:10.1016/s0006-8993(03)03170-6 |
| | 4-Cyano-3-methylisoquinoline Preparation Products And Raw materials |
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