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| | METHYL 4-AMINO-6-INDOLECARBOXYLATE Basic information |
| | METHYL 4-AMINO-6-INDOLECARBOXYLATE Chemical Properties |
| Melting point | 160-163 °C(Solv: benzene (71-43-2)) | | Boiling point | 429.8±25.0 °C(Predicted) | | density | 1.339±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 17.03±0.30(Predicted) | | Appearance | Light brown to brown Solid | | CAS DataBase Reference | 121561-15-7(CAS DataBase Reference) |
| | METHYL 4-AMINO-6-INDOLECARBOXYLATE Usage And Synthesis |
| Uses | In the pharmaceutical field, methyl 4-amino-6-indolecarboxylate is mainly used as an organic synthesis intermediate to synthesize a variety of drug compounds, such as methyl 4-amino-6-indolecarboxylate hydrochloride, which is used in drug synthesis. | | Synthesis | To a solution of methyl 4-[(E)-2-(dimethylamino)vinyl]-3,5-dinitrobenzoate (D200) (10 g, 34 mmol, 1 eq.) in methanol (250 ml) was added 10% palladium charcoal (50% wet, 1.0 g, 5% w/w). The reaction mixture was stirred under hydrogen atmosphere for 7 hours. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The residue was ground with ethyl acetate/isohexane mixed solvent to afford methyl 4-amino-1H-indole-6-carboxylate (D201) (5 g, 77% yield) as a dark pink solid. Mass spectrometry analysis showed [M+H]+ = 191.0 and retention time (RT) = 1.20 min. | | References | [1] Tetrahedron Letters, 2007, vol. 48, # 45, p. 7990 - 7993
[2] Patent: WO2004/50619, 2004, A1. Location in patent: Page 57
[3] Patent: WO2005/58915, 2005, A1. Location in patent: Page/Page column 18 |
| | METHYL 4-AMINO-6-INDOLECARBOXYLATE Preparation Products And Raw materials |
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