- 3-Fluorophenylacetic acid
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- $0.00 / 25Kg/Drum
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2026-04-18
- CAS:331-25-9
- Min. Order: 1Kg/Drum
- Purity: 99%
- Supply Ability: 100mt/year
- 3-Fluorophenylacetic acid
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- $9.00 / 1KG
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2025-09-25
- CAS:331-25-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 3-Fluorophenylacetic acid Basic information |
| | 3-Fluorophenylacetic acid Chemical Properties |
| Melting point | 42-44 °C (lit.) | | Boiling point | 151 °C | | density | 1.1850 (estimate) | | Fp | >230 °F | | storage temp. | Sealed in dry,Room Temperature | | pka | 4.10±0.10(Predicted) | | form | powder to crystal | | color | White to Almost white | | Water Solubility | Slightly soluble in chloroform and methanol. Insoluble in water. | | BRN | 775898 | | InChI | InChI=1S/C8H7FO2/c9-7-3-1-2-6(4-7)5-8(10)11/h1-4H,5H2,(H,10,11) | | InChIKey | YEAUYVGUXSZCFI-UHFFFAOYSA-N | | SMILES | C1(CC(O)=O)=CC=CC(F)=C1 | | CAS DataBase Reference | 331-25-9(CAS DataBase Reference) | | NIST Chemistry Reference | M-fluorophenylacetic acid(331-25-9) | | EPA Substance Registry System | Benzeneacetic acid, 3-fluoro- (331-25-9) |
| Hazard Codes | Xi | | Risk Statements | 38-36/37/38 | | Safety Statements | 22-24/25-36-26 | | WGK Germany | 3 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29163900 | | Storage Class | 13 - Non Combustible Solids |
| | 3-Fluorophenylacetic acid Usage And Synthesis |
| Chemical Properties | White to pale yellow or light beige crystalline | | Uses | 3-Fluorophenylacetic acid has been used as building block to synthesize the pentaamine and bis-heterocyclic libraries. It is also used as a medicine intermediates. | | Uses | 3-Fluorophenylacetic acid has been used as building block to synthesize the pentaamine and bis-heterocyclic libraries. | | Synthesis | Preparation of m-fluorophenylacetic acid: 350 g of 32% HCl and 250 g of 3-fluoroaniline were added to the reaction flask, heated and stirred until dissolved clear. Cool down to -5 to 5 , 20 g tetramethyl ammonium chloride and 20 g copper chloride. Acetone solution containing 300 g of vinylidene chloride was added dropwise. Maintaining the temperature, slowly add dropwise a solution containing 230 g of isopropyl nitrite and 200 g of acetone. Hold the reaction for 2 hours. The reaction was completed and quenched. Dichloromethane was added and extracted and distilled and collected to give 1-(2,2,2-trichloroethyl)-3-fluorobenzene 398 g. A three-necked flask was protected with nitrogen and 500 g of water and 60 g of p-toluenesulfonic acid were added. Heated to 80-95C. 300g of intermediate 1-(2,2,2-trichloroethyl)-3-fluorobenzene was added dropwise. Dropwise addition was completed and the reaction was held for 8 hours. The reaction was completed. The system was quenched by adding dropwise to ice water at reduced temperature. Filtered, washed with water, dried and recrystallized with dichloroethane to obtain the pure m-fluorophenylacetic acid 151.2 g, HPLC purity greater than 99 wt%.
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| | 3-Fluorophenylacetic acid Preparation Products And Raw materials |
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