7-Bromo-1,2,3,4-tetrahydro-isoquinoline

7-Bromo-1,2,3,4-tetrahydro-isoquinoline Suppliers list

Company Name:	Shanghai Amico Chemicals Co. LTD Gold
Tel:	微信 18019252918 18019252918
Email:	1454668768@qq.com

Company Name:	Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd. Gold
Tel:	15720605021
Email:	zhang_lei@jsnchem.com

7-Bromo-1,2,3,4-tetrahydro-isoquinoline manufacturers

7-Bromo-1,2,3,4-tetrahydro-isoquinoline Basic information

Product Name:	7-Bromo-1,2,3,4-tetrahydro-isoquinoline
Synonyms:	CHEMBRDG-BB 4002740;B90106;Isoquinoline, 7-bromo-1,2,3,4-tetrahydro-;7-BroMo-1,2,3,4-tetrahydroisoquinoline, 97%, 97%;7-Bromo-1,2,3,4-tetrahydroisoquinoL;7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE ISO 9001：2015 REACH;7-Bromo-1,2,3,4-tetrahydro-isoquinoline
CAS:	17680-55-6
MF:	C9H10BrN
MW:	212.09
EINECS:
Product Categories:
Mol File:	17680-55-6.mol

7-Bromo-1,2,3,4-tetrahydro-isoquinoline Chemical Properties

Melting point	32-35°C
Boiling point	282.9±40.0 °C(Predicted)
density	1.428±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
form	solid
pka	9.14±0.20(Predicted)
color	White
Water Solubility	Insoluble in water.
InChI	InChI=1S/C9H10BrN/c10-9-2-1-7-3-4-11-6-8(7)5-9/h1-2,5,11H,3-4,6H2
InChIKey	OYODEQFZAJVROF-UHFFFAOYSA-N
SMILES	C1C2=C(C=CC(Br)=C2)CCN1

Safety Information

MSDS Information

7-Bromo-1,2,3,4-tetrahydro-isoquinoline Usage And Synthesis

Uses	7-Bromo-1,2,3,4-tetrahydroisoquinoline is used as a pharmaceutical intermediate.
Synthesis Reference(s)	The Journal of Organic Chemistry, 63, p. 4116, 1998 DOI: 10.1021/jo972184e
Synthesis	181514-35-2 17680-55-6 The general procedure for the synthesis of 7-bromo-1,2,3,4-tetrahydroisoquinoline from N-trifluoroacetyl-7-bromo-1,2,3,4-tetrahydroisoquinoline was as follows: 1-(7-bromo-3,4-dihydro-1H-isoquinolin-2-yl)-2,2,2-trifluoroacetophenone (14.3 g, 46.4 mmol) was added to a mixture of methanol (50 mL) and saturated sodium carbonate solution ( 50 mL) to a mixture of methanol (50 mL) and saturated sodium carbonate solution (50 mL). The reaction mixture was stirred at 60 °C for 1 hour. After completion of the reaction, the mixture was concentrated and the residue was extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and brine, and then dried over anhydrous sodium sulfate. After evaporation of the solvent, the crude product was purified by column chromatography to afford the light yellow solid product 7-bromo-1,2,3,4-tetrahydroisoquinoline (8.4 g, 85% yield). Mass spectrometry analysis showed m/z 213.8 (M + 1).
References	[1] Patent: WO2008/76954, 2008, A2. Location in patent: Page/Page column 51 [2] Patent: US2008/81803, 2008, A1. Location in patent: Page/Page column 34-35

7-Bromo-1,2,3,4-tetrahydro-isoquinoline Preparation Products And Raw materials

Raw materials

Tag:7-Bromo-1,2,3,4-tetrahydro-isoquinoline(17680-55-6) Related Product Information

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