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| | 2-Methyl-4-methoxybenzenamine Basic information |
| | 2-Methyl-4-methoxybenzenamine Chemical Properties |
| Melting point | 13-14 °C(lit.) | | Boiling point | 248-249 °C(lit.) | | density | 1.065 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.565(lit.) | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Acetonitrile (Slightly), Chloroform (Slightly), DMSO, Methanol (Slightly) | | form | Oil | | pka | 5.05±0.10(Predicted) | | color | Light Brown to Very Dark Red | | Water Solubility | insoluble, <0.1 g/100 mL at 21.5 ºC | | BRN | 774727 | | Henry's Law Constant | 8.2×101 mol/(m3Pa) at 25℃, HSDB (2015) | | Stability: | Stable. May be light or air-sensitive. Combustible. Incompatible with acids, strong oxidizing agents. | | InChI | 1S/C8H11NO/c1-6-5-7(10-2)3-4-8(6)9/h3-5H,9H2,1-2H3 | | InChIKey | CDGNLUSBENXDGG-UHFFFAOYSA-N | | SMILES | COc1ccc(N)c(C)c1 | | CAS DataBase Reference | 102-50-1(CAS DataBase Reference) | | IARC | 3 (Vol. 27, Sup 7) 1987 | | NIST Chemistry Reference | Benzenamine, 4-methoxy-2-methyl-(102-50-1) | | EPA Substance Registry System | m-Cresidine (102-50-1) |
| | 2-Methyl-4-methoxybenzenamine Usage And Synthesis |
| Chemical Properties | brick red crystals or liquid | | Uses | 4-Methoxy-2-methylaniline is a reagent used in organic synthesis of more complex compounds that have a more specific function. For example, enzyme inhibitors. | | Definition | ChEBI: Meta-Cresidine is a member of methoxybenzenes. | | General Description | Crystals or brick red liquid. | | Air & Water Reactions | Sensitive to prolonged exposure to air and light. Insoluble in water. | | Reactivity Profile | 2-Methyl-4-methoxybenzenamine neutralizes acids in weakly exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts with oxidizing agents . | | Health Hazard | ACUTE/CHRONIC HAZARDS: 2-Methyl-4-methoxybenzenamine is a local irritant. When heated to decomposition it emits toxic fumes of NOx. 2-Methyl-4-methoxybenzenamine is an experimental animal carcinogen. | | Fire Hazard | 2-Methyl-4-methoxybenzenamine is probably combustible. | | Safety Profile | Suspected carcinogen
with experimental carcinogenic and
tumorigenic data. Mutation data reported.
When heated to decomposition it emits
toxic fumes of NOx. | | Synthesis | GENERAL PROCEDURE: 3-methyl-4-nitroanisole (1.0 mmol), B2(OH)4 (5.0 eq., 5.0 mmol) and H2O (3.0 mL) were added to a 10 mL reaction tube. The reaction mixture was stirred at 80 °C for 8 hours. After completion of the reaction (monitored by TLC), the mixture was cooled to room temperature and extracted with ethyl acetate (3 x 20 mL). The organic phases were combined, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 2-methyl-4-methoxyaniline. | | References | [1] Analytical Chemistry, 1992, vol. 64, # 8, p. 837 - 842
[2] ChemCatChem, 2017, vol. 9, # 16, p. 3236 - 3244
[3] Synlett, 2018, vol. 29, # 13, p. 1765 - 1768
[4] Tetrahedron, 2017, vol. 73, # 27-28, p. 3898 - 3904
[5] Helvetica Chimica Acta, 1924, vol. 7, p. 698 |
| | 2-Methyl-4-methoxybenzenamine Preparation Products And Raw materials |
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