- 2-AMINO-5-FLUOROPHENOL
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- $0.00 / 1KG
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2026-01-05
- CAS:53981-24-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20 mt
- 2-AMINO-5-FLUOROPHENOL
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- $1.00 / 1KG
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2019-07-06
- CAS:53981-24-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: Customized
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| | 2-AMINO-5-FLUOROPHENOL Basic information |
| | 2-AMINO-5-FLUOROPHENOL Chemical Properties |
| Melting point | 38°C | | Boiling point | 246.1±25.0 °C(Predicted) | | density | 1.347±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMSO, Methanol | | form | Solid | | pka | 8.76±0.10(Predicted) | | color | Dark Beige | | Water Solubility | Slightly soluble in water. | | Sensitive | Air Sensitive | | InChI | InChI=1S/C6H6FNO/c7-4-1-2-5(8)6(9)3-4/h1-3,9H,8H2 | | InChIKey | IIDUNAVOCYMUFB-UHFFFAOYSA-N | | SMILES | C1(O)=CC(F)=CC=C1N | | CAS DataBase Reference | 53981-24-1(CAS DataBase Reference) |
| | 2-AMINO-5-FLUOROPHENOL Usage And Synthesis |
| Chemical Properties | Dark Beige Solid | | Uses | 2-Amino-5-fluorophenol is a fluoroaniline metabolite. 2-Amino-5-fluorophenol is used as organic intermediate. To synthesize the intermediate (2-amino-5-fluorophenol-N, N, O-triacetic acid trimethyl ester) of indicator which used in the determination Mg2+ by NMR, three feasible reactions were experimentally carried out, such as alkaline hydrolysis, catalytic hydrogenation and esterification. | | Synthesis | The general procedure for the synthesis of 2-amino-5-fluorophenol from 5-fluoro-2-nitrophenol is as follows: 5-fluoro-2-nitrophenol (2.50 g, 15.9 mmol, commercially available from e.g., Aldrich) was dissolved in ethanol (50 ml), and 10% palladium-carbon catalyst (980 mg) was added for the hydrogenation reaction, which lasted for 1.5 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. The solid residue obtained was dissolved in ether, followed by addition of an equal volume of cyclohexane. The ether was removed by vacuum distillation at room temperature to give a light gray solid product. The product was filtered and washed with cyclohexane to give 2-amino-5-fluorophenol (1.90 g, 94% yield). Elemental analysis measured values: C, 56.4; H, 4.8; N, 10.9. theoretical values (C6H6FNO): C, 56.7; H, 4.8; N, 11.0%. | | References | [1] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9742 - 9753
[2] Patent: WO2010/94643, 2010, A1. Location in patent: Page/Page column 46
[3] Patent: US5238908, 1993, A
[4] Patent: US5393735, 1995, A
[5] Chemistry - A European Journal, 2011, vol. 17, # 33, p. 9076 - 9082 |
| | 2-AMINO-5-FLUOROPHENOL Preparation Products And Raw materials |
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