N-[2-Carbamoyl-5-(4-chloro-phenyl)-thiophen-3-yl]-succinamic acid

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Company Name: Wuhan Chemwish Technology Co., Ltd  
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Company Name: Shanghai Sinch Parmaceuticals Tech. Co. Ltd.  
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N-[2-Carbamoyl-5-(4-chloro-phenyl)-thiophen-3-yl]-succinamic acid Basic information
Product Name:N-[2-Carbamoyl-5-(4-chloro-phenyl)-thiophen-3-yl]-succinamic acid
Synonyms:Butanoic acid, 4-[[2-(aminocarbonyl)-5-(4-chlorophenyl)-3-thienyl]amino]-4-oxo-;N-[2-Carbamoyl-5-(4-chloro-phenyl)-thiophen-3-yl]-succinamic acid
CAS:676995-91-8
MF:C15H13ClN2O4S
MW:352.79
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Mol File:Mol File
N-[2-Carbamoyl-5-(4-chloro-phenyl)-thiophen-3-yl]-succinamic acid Structure
N-[2-Carbamoyl-5-(4-chloro-phenyl)-thiophen-3-yl]-succinamic acid Chemical Properties
Boiling point 637.9±55.0 °C(Predicted)
density 1.497±0.06 g/cm3(Predicted)
pka4.59±0.10(Predicted)
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MSDS Information
N-[2-Carbamoyl-5-(4-chloro-phenyl)-thiophen-3-yl]-succinamic acid Usage And Synthesis
UsesFtsZ-IN-10 is a bacterial division inhibitor that interferes with the normal assembly of FtsZ. FtsZ-IN-10 specifically binds to Bacillus subtilis FtsZ monomers, thereby affecting their polymerization behavior. FtsZ-IN-10 may also activate nucleotide-free archaeal FtsZ to form ordered polymers. FtsZ-IN-10 can hinder the localization of FtsZ in the Z ring and inhibit bacterial cell division. Chlorinated analogs of FtsZ-IN-10 show the ability to inhibit the growth of antibiotic-resistant clinical isolates such as Staphylococcus aureus and Enterococci[1].
References[1] Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ DOI:10.1021/cb400208z
N-[2-Carbamoyl-5-(4-chloro-phenyl)-thiophen-3-yl]-succinamic acid Preparation Products And Raw materials
Tag:N-[2-Carbamoyl-5-(4-chloro-phenyl)-thiophen-3-yl]-succinamic acid(676995-91-8) Related Product Information
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