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| | 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE Basic information |
| | 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE Chemical Properties |
| Melting point | 250-255 °C (lit.) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | soluble in Methanol | | form | Solid | | color | White to Almost white | | InChI | InChI=1S/C8H10ClNO.ClH/c1-11-8-3-2-6(5-10)4-7(8)9;/h2-4H,5,10H2,1H3;1H | | InChIKey | IKWWOZCEHOYKAO-UHFFFAOYSA-N | | SMILES | NCC1=CC=C(OC)C(Cl)=C1.[H]Cl | | CAS DataBase Reference | 41965-95-1(CAS DataBase Reference) |
| Hazard Codes | T | | Risk Statements | 25-37/38-41 | | Safety Statements | 26-36/37-45-39 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | Hazard Note | Toxic | | HazardClass | IRRITANT | | HazardClass | 6.1 | | HS Code | 2922290090 |
| | 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White powder solid | | Synthesis | General procedure for the synthesis of 3-chloro-4-methoxybenzylamine hydrochloride from 4-methoxybenzylamine: acetic acid (100 ml) was slowly added to 4-methoxybenzylamine (100 g) at 25-30 °C. Subsequently, additional acetic acid (750 ml) was added to the reaction mixture. Sulfonyl chloride (87.84 ml) was slowly added dropwise to the reaction mixture at 20-25 °C and stirred continuously for 6 h at the same temperature. After completion of the reaction, methyl tert-butyl ether (850 ml) was added to the reaction mixture at 25-30 °C. The reaction mixture was cooled to 15-20°C and stirring was continued at this temperature for 1 hour. The precipitated solid product was filtered, washed with methyl tert-butyl ether and dried to give 3-chloro-4-methoxybenzylamine hydrochloride. Yield: 118 g. | | References | [1] Synthesis, 2003, # 3, p. 403 - 407
[2] Synthetic Communications, 2000, vol. 30, # 14, p. 2609 - 2612
[3] Tetrahedron, 2003, vol. 59, # 35, p. 6991 - 7009
[4] Organic letters, 2001, vol. 3, # 25, p. 4063 - 4066
[5] Patent: WO2015/1567, 2015, A1. Location in patent: Page/Page column 21 |
| | 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE Preparation Products And Raw materials |
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