|
|
| | 1-(4-Fluorophenyl)piperazine Basic information |
| | 1-(4-Fluorophenyl)piperazine Chemical Properties |
| Melting point | 30-33 °C (lit.) | | Boiling point | 118-123 °C/0.1 mmHg (lit.) | | density | 1.0 | | refractive index | 1.5585-1.5605 | | Fp | >230 °F | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) | | pka | 8.93±0.10(Predicted) | | form | Liquid After Melting | | color | Clear yellow | | Water Solubility | Insoluble in water. | | Sensitive | Air Sensitive | | BRN | 610723 | | InChI | 1S/C10H13FN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2 | | InChIKey | AVJKDKWRVSSJPK-UHFFFAOYSA-N | | SMILES | Fc1ccc(cc1)N2CCNCC2 | | CAS DataBase Reference | 2252-63-3(CAS DataBase Reference) | | NIST Chemistry Reference | 1-(P-fluorophenyl)piperazine(2252-63-3) |
| Hazard Codes | Xn,T,C | | Risk Statements | 22-36/37/38-20/21/22 | | Safety Statements | 26-36 | | RIDADR | 2811 | | WGK Germany | 2 | | Hazard Note | Toxic/Corrosive | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 1-(4-Fluorophenyl)piperazine Usage And Synthesis |
| Chemical Properties | clear yellowish liquid after melting | | Uses | 1-(4-Fluorophenyl)piperazine is a major metabolite of Niaparazine, a sedative, hypnotic drug. Metabolites of Niaprazine occurred by N-dealkylation, N-dearylation, aromatic hydroxylation and N-oxidatio
n. | | Uses | 1-(4-Fluorophenyl)piperazine was used in the synthesis of N,N-disubstituted piperazine. It is a major metabolite of niaparazine, a sedative, a hypnotic drug. | | Synthesis | Weighing 4-fluoroaniline 9.2mL (0.10mol), bis(2-chloroethyl)amine hydrochloride 17.85g (0.10mol) and diethylene glycol monomethyl ether 25mL in a 100mL three-necked flask, and placed in the reflux device equipped with a reflux device WBFY-201-type microcomputer microwave chemical reactor, reflux, the microwave radiation power of 800W, the reaction time is 3min. At the end of the reaction, the reaction solution was cooled and then distilled under reduced pressure to remove diethylene glycol monomethyl ether, and the solvent was recovered for use. The residue was added to a small amount of ethanol, add a certain amount of ether solution, to be clarified by the mixture, at this time, a large number of solids precipitated, the hydrochloride was dissolved in 30mL of water, the PH value was adjusted to 12 with 40% sodium hydroxide, ethyl acetate extraction for 2 times (2 40mL), and then washed with water and saturated saline respectively for 1 time, the organic layer was dried with anhydrous sodium sulfate, filtered, concentrated, and then obtained by distillation under reduced pressure 1- (4-fluorophenyl)piperazine light yellow liquid 13.97g, yield 77.6%. |
| | 1-(4-Fluorophenyl)piperazine Preparation Products And Raw materials |
|