| Company Name: |
Changzhou PBpharmaceutical R&D Co.,Ltd |
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0519-83990708 |
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info@pbpharm.com |
| Products Intro: |
Product Name:5,6,7,8-Tetrahydro-1,6-naphthyridine
CAS:80957-68-2
Purity:95%+ Package:10mg, 50mg,100MG,250mg,500MG,1G,5G,25G,100G
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| | 2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE Basic information |
| Product Name: | 2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE | | Synonyms: | 5,6,7,8-TETRAHYDRO-[1,6]NAPHTHYRIDINE;1,6-Naphthyridine, 5,6,7,8-tetrahydro-;5,6,7,8-tetrahydro-1,6-naphthyridine(SALTDATA: 2HCl 0.5H2O);5,6,7,8-tetrahydro-1,6-naphthyridine HCl Salt;5,6,7,8-Tetrahydro-1,6phthyridine;5,6,7,8-tetrahydropyrido[4,3-b]pyridine | | CAS: | 80957-68-2 | | MF: | C8H10N2 | | MW: | 134.18 | | EINECS: | | | Product Categories: | Heterocycle-Pyridine series;CHIRAL CHEMICALS | | Mol File: | 80957-68-2.mol | ![2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE Structure](CAS/GIF/80957-68-2.gif) |
| | 2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE Chemical Properties |
| Boiling point | 247.6±30.0 °C(Predicted) | | density | 1.068±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 7.95±0.20(Predicted) |
| | 2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE Usage And Synthesis |
| Uses | 5,6,7,8-Tetrahydro-1,6-naphthyridine is used in the synthetic preparation of quinolizidinone carboxylic acid selective M1 allosteric modulators. | | Synthesis | 6-Benzyl-5,6,7,8-tetrahydro-1,6-naphthyridine (3.9 g, 17.4 mmol) was used as a starting material and dissolved in 60 mL of acetic acid. A 0.4 g palladium/carbon catalyst was added. The reaction solution was transferred to a hydrogen reaction vessel and after three displacements with hydrogen, the reaction was carried out at 50 °C for 48 hours. After completion of the reaction, the catalyst was removed by filtration. The solvent was removed by distillation under reduced pressure and the resulting crude product was purified by column chromatography using a solvent mixture of dichloromethane and methanol (5:1, v/v) to afford the target product 5,6,7,8-tetrahydro-1,6-naphthyridine (1.48 g, 64% yield). | | References | [1] Chemical and Pharmaceutical Bulletin, 1984, vol. 32, # 7, p. 2522 - 2529
[2] Patent: CN108250128, 2018, A. Location in patent: Paragraph 0638; 0640; 0643; 0644
[3] Patent: WO2009/56556, 2009, A1. Location in patent: Page/Page column 41
[4] Journal of Medicinal Chemistry, 2004, vol. 47, # 21, p. 5167 - 5182 |
| | 2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE Preparation Products And Raw materials |
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