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| | 2-(DIFLUOROMETHOXY)ANILINE Basic information |
| | 2-(DIFLUOROMETHOXY)ANILINE Chemical Properties |
| Boiling point | 205 °C(lit.) | | density | 1.272 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.505(lit.) | | Fp | 199 °F | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | liquid | | pka | 2.93±0.10(Predicted) | | Specific Gravity | 1.272 | | color | Clear, dark red | | BRN | 2718520 | | InChI | 1S/C7H7F2NO/c8-7(9)11-6-4-2-1-3-5(6)10/h1-4,7H,10H2 | | InChIKey | CGNAIUUCOVWLLL-UHFFFAOYSA-N | | SMILES | Nc1ccccc1OC(F)F | | CAS DataBase Reference | 22236-04-0(CAS DataBase Reference) |
| Hazard Codes | Xn,T | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | RIDADR | 2811 | | WGK Germany | 3 | | Hazard Note | Toxic | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29222990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral |
| | 2-(DIFLUOROMETHOXY)ANILINE Usage And Synthesis |
| Uses |
2-(Difluoromethoxy)aniline is used as an organic intermediate.
| | Synthesis | Iron powder (5 eq.) was added to a solution of 2-(difluoromethoxy)nitrobenzene (1 eq.) in MeOH/MeCOOH (1:1). The reaction mixture was heated at 50 C under N2
The reaction mixture was heated at 50 C for 3 hours under N2 . The reaction mixture was concentrated under vacuum. To the residue, EtOAc (100 mL) and 1 m NaOH were added.
(50mL) to the residue. Remove the precipitate by centrifugation. The aqueous layer was separated. Extract the aqueous layer with EtOAc (3 50 mL). Combine the organic layer and extract. Dry the combined organic layers and extract with MgSO 4.
Extraction. Filter the combined organic layer and extract. Concentrate the combined organic layer and extract in vacuum. |
| | 2-(DIFLUOROMETHOXY)ANILINE Preparation Products And Raw materials |
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